Abemaciclib

SZ CAT No:	SZ-A077001
CAS No	1231929-97-7
Mol.F.	C27H32F2N8
Mol.Wt.	506.6
Inv. Status	In Stock
Rel. CAS No	2089320-70-5 (HCl salt) ; 1231930-82-7 (Methanesulfonic acid)
Shipping Condition	Ambient Temperature

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Chemical Name: N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

Synonym: Verzenio ; Verzenios

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CC(N1C2=CC(C3=NC(NC4=CC=C(CN5CCN(CC)CC5)C=N4)=NC=C3F)=CC(F)=C2N=C1C)C

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry
By Martinez-Chavez, Alejandra; Rosing, Hilde; Hillebrand, Michel; Tibben, Matthijs; Schinkel, Alfred H.; Beijnen, Jos H.
From Analytical and Bioanalytical Chemistry (2019), 411(20), 5331-5345

Abemaciclib is chemically N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine. It is also known as Verzenio ; Verzenios. Abemaciclib is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Abemaciclib

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SZ CAT No:	: SZ-A077001
CAS No	: 1231929-97-7
Mol.F.	: C27H32F2N8
Mol.Wt.	: 506.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-A077D02
CAS No	: 2088650-71-7
Mol.F.	: C27H22D10F2N8
Mol.Wt.	: 516.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077D03
CAS No	: 1809251-51-1
Mol.F.	: C27H27D5F2N8
Mol.Wt.	: 511.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077D04
CAS No	: NA
Mol.F.	: C27H25D7F2N8
Mol.Wt.	: 513.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077D01
CAS No	: 2088650-53-5
Mol.F.	: C27H24D8F2N8
Mol.Wt.	: 514.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077003
CAS No	: 1180132-17-5
Mol.F.	: C12H20N4
Mol.Wt.	: 220.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077005
CAS No	: 1231930-42-9
Mol.F.	: C15H13ClF2N4
Mol.Wt.	: 322.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077006
CAS No	: 414881-11-1
Mol.F.	: C12H19N3
Mol.Wt.	: 205.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-A077007
CAS No	: NA
Mol.F.	: C27H33FN8
Mol.Wt.	: 488.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077008
CAS No	: NA
Mol.F.	: C15H14F2N4
Mol.Wt.	: 288.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077004
CAS No	: 1231930-57-6
Mol.F.	: C25H28F2N8
Mol.Wt.	: 478.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-A077002
CAS No	: NA
Mol.F.	: C27H31F2N9O
Mol.Wt.	: 535.6
Inv. Status	: Inquire