Pyrimethamine BP Impurity 3

Development of a simple, rapid, and robust liquid chromatographic method for the simultaneous determination of sulfalene, sulfadoxine, and pyrimethamine in tablets
Yonah H.Mwalwisi, Ludwig Hoellein, Eliangiringa Kaale, UlrikeHolzgrabe
Journal of Pharmaceutical and Biomedical Analysis Volume 129, 10 September 2016, Pages 558-570
 
Development of 2,4-Diaminopyrimidines as Antimalarials Based on Inhibition of the S108N and C59R+S108N Mutants of Dihydrofolate Reductase from Pyrimethamine-Resistant Plasmodium falciparum
Bongkoch Tarnchompoo, Chawanee Sirichaiwat, Worrapong Phupong, Chakapong Intaraudom, Worachart Sirawaraporn, Sumalee Kamchonwongpaisan, Jarunee Vanichtanankul, Yodhathai Thebtaranonth, and Yongyuth Yuthavong
J. Med. Chem. 2002, 45, 6, 1244–1252
 
Validated HPTLC Method for Simultaneous Analysis of Pyrimethamine and Sulphadoxine in Pharmaceutical Dosage Forms
S. Meena and S. M. Sandhya
Hindawi Publishing Corporation Journal of Chemistry Volume 2013, Article ID 698490, 6 pages

Pyrimethamine BP Impurity 3 is chemically 4-Amino-5-(4-chlorophenyl)-6-ethylpyrimidin-2(1H)-one 2,2,2-trifluoroacetate. Pyrimethamine BP Impurity 3 is supplied with detailed characterization data compliant with regulatory guideline. Pyrimethamine BP Impurity 3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Pyrimethamine.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.