N-Nitroso Metoprolol

Identification of a new by-product detected in metoprolol tartrate
magnus erickson,$ karl-erik karlsson,$ bo lamm,§ sam larsson,$ lars a. svensson$ and jorgen vessman
Journal of Pharmaceutical & Biomedical Analysis, Vol. 13, No. 4/5, pp. 567-574, 1995
 
An improved validated HPLC method for separation of metoprolol and hydrochlorothiazide impurities in metoprolol and hydrochlorothiazide tablets
Avinash S. Patil, Shakil S. Sait, Abhijit Deshamukh and Girish Deshpande
Der Pharmacia Lettre, 2015, 7 (2):183-190
 
Simultaneous Quantitative Determination of Metoprolol, Atorvastatin and Ramipril in Capsules by a Validated Stability-Indicating RP-UPLC Method
raja kumar seshadri * 1 , makarand madhukar desai 1 , thummala veera raghavaraju 1 , deepa krishnan 1 , dama venugopala rao 1 , ivon elisha chakravarthy
Sci Pharm. 2010; 78: 821–834
 
Development and validation of a stability indicating RP-HPLC method for determination of metoprolol succinate in pharmaceutical dosage forms
1CH. Naveen Kumar*, 1 Saraswathi Mannuri, 1Vijaya Kuchana and 2N. Kannappan
Der Pharmacia Sinica, 2014, 5(6):69-78
 

N-Nitroso Metoprolol is chemically N-(2-Hydroxy-3-(4-(2-methoxyethyl)phenoxy)propyl)-N-isopropylnitrous amide. N-Nitroso Metoprolol is supplied with detailed characterization data compliant with regulatory guideline. N-Nitroso Metoprolol can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Metoprolol.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.