Loratadine 4-Hydroxymethyl Impurity (USP)

LC determination of loratadine and related impurities
F.J. Rupe´rez, H. Ferna´ndez, C. Barbas
Journal of Pharmaceutical and Biomedical Analysis 29 (2002) 35–41
 
Measurement and Correlation of Solubility of Loratadine in Different Pure Solvents and Binary Mixtures
Xiujuan Yang,† Shui Wang,† and Jidong Wang
J. Chem. Eng. Data 2017, 62, 1, 391–397

Loratadine 4-Hydroxymethyl Impurity (USP) is chemically Ethyl 4-[8-chloro-5,6-dihydro-4-(hydroxy methyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine carboxylate ; . It is also known as 4-Hydroxymethyl Loratadine (USP). Loratadine 4-Hydroxymethyl Impurity (USP) is supplied with detailed characterization data compliant with regulatory guideline. Loratadine 4-Hydroxymethyl Impurity (USP) can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Loratadine.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.