Cisatracurium EP Impurity O (TFA salt)

HPLC determination of cisatracurium besylate and propofol mixtures with LC-​MS identification of degradation products
By Zhang H; Wang P; Bartlett M G; Stewart J T
From Journal of pharmaceutical and biomedical analysis (1998), 16(7), 1241-9
 

Cisatracurium EP Impurity O (TFA salt) is chemically (1R,2R)-1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-2-[3-[[5-(prop-2-enoyloxy)pentyl]oxy]-3-oxopropyl]-1,2,3,4-tetrahydroisoquinolinium (as per EP);(1R,2R)-2-(3,11-Dioxo-4,10-dioxa-12-tridecenyl)-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) (as per USP). It is also known as cis-Monoacrylate Cisatracurium. Cisatracurium EP Impurity O (TFA salt) is supplied with detailed characterization data compliant with regulatory guideline. Cisatracurium EP Impurity O (TFA salt) can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Cisatracurium.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.