Ciprofloxacin EP Impurity D (TFA salt)

Determination of ciprofloxacin and its impurities by capillary zone electrophoresis
Katarzyna Michalska∗, Genowefa Pajchel, Stefan Tyski
Journal of Chromatography A, 1051 (2004) 267–272
 
MSMPR Studies of Ciprofloxacin From Pure API and From Crude API: The Role of Impurities on Solubility and Kinetics
Gerard Capellades, Helena Wiemeyer, and Allan S. Myerson
Cryst. Growth Des. 2019, 19, 7, 4008–4018
 
High-Performance Thin-Layer Chromatography with Densitometry for the Determination of Ciprofloxacin and Impurities in Drugs
Jan Krzek, Urszula Hubicka, Justyna Szczepańczyk
Journal of AOAC INTERNATIONAL, Volume 88, Issue 5, 1 September 2005, Pages 1530–1536
 
Development and Validation of a Stability-Indicating HPLC Method for Determination of Ciprofloxacin Hydrochloride and its Related Compounds in Film-Coated Tablets
B. Aksoy, İ. Küçükgüzel & S. Rollas
Chromatographia volume 66, pages57–63(2007)

Ciprofloxacin EP Impurity D (TFA salt) is chemically 2,2,2-Trifluoroacetic acid compound with 7-chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (1:1) ; 2,2,2-trifluoroacetic acid compound with 7-Chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (as per USP). It is also known as Ciprofloxacin USP Related Compound A. Ciprofloxacin EP Impurity D (TFA salt) is supplied with detailed characterization data compliant with regulatory guideline. Ciprofloxacin EP Impurity D (TFA salt) can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Ciprofloxacin .

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.