Abemaciclib D8

SZ目录编号:	SZ-A077D01
CAS 号	2088650-53-5
分子式	C27H24D8F2N8
分子量	514.7
投资状态	Custom Synthesis

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化学名称: N-(5-((4-Ethylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

微笑: CC(N1C2=CC(C3=NC(NC4=CC=C(CN5C([2H])([2H])C([2H])([2H])N(CC)C([2H])([2H])C5([2H])[2H])C=N4)=NC=C3F)=CC(F)=C2N=C1C)C

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry
By Martinez-Chavez, Alejandra; Rosing, Hilde; Hillebrand, Michel; Tibben, Matthijs; Schinkel, Alfred H.; Beijnen, Jos H.
From Analytical and Bioanalytical Chemistry (2019), 411(20), 5331-5345

Abemaciclib D8 is chemically N-(5-((4-Ethylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine. Abemaciclib D8 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib D8 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

SZ目录编号:	: SZ-A077001
CAS 号	: 1231929-97-7
分子式	: C27H32F2N8
分子量	: 506.6
投资状态	: In Stock
Rel. CAS No	: 2089320-70-5 (HCl salt) ; 1231930-82-7 (Methanesulfonic acid)

SZ目录编号:	: SZ-A077003
CAS 号	: 1180132-17-5
分子式	: C12H20N4
分子量	: 220.3
投资状态	: Custom Synthesis
Rel. CAS No	: 1197331-99-9 (HCl salt)

SZ目录编号:	: SZ-A077004
CAS 号	: 1231930-57-6
分子式	: C25H28F2N8
分子量	: 478.6
投资状态	: In Stock
Rel. CAS No	: 2139329-63-6 (TFA salt)

Abemaciclib D8

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SZ目录编号:	: SZ-A077D02
CAS 号	: 2088650-71-7
分子式	: C27H22D10F2N8
分子量	: 516.7
投资状态	: Custom Synthesis

SZ目录编号:	: SZ-A077D03
CAS 号	: 1809251-51-1
分子式	: C27H27D5F2N8
分子量	: 511.6
投资状态	: Custom Synthesis

SZ目录编号:	: SZ-A077D04
CAS 号	: NA
分子式	: C27H25D7F2N8
分子量	: 513.7
投资状态	: Custom Synthesis

SZ目录编号:	: SZ-A077D01
CAS 号	: 2088650-53-5
分子式	: C27H24D8F2N8
分子量	: 514.7
投资状态	: Custom Synthesis

SZ目录编号:	: SZ-A077005
CAS 号	: 1231930-42-9
分子式	: C15H13ClF2N4
分子量	: 322.7
投资状态	: In Stock

SZ目录编号:	: SZ-A077006
CAS 号	: 414881-11-1
分子式	: C12H19N3
分子量	: 205.3
投资状态	: In Stock

SZ目录编号:	: SZ-A077007
CAS 号	: NA
分子式	: C27H33FN8
分子量	: 488.6
投资状态	: Custom Synthesis

SZ目录编号:	: SZ-A077008
CAS 号	: NA
分子式	: C15H14F2N4
分子量	: 288.3
投资状态	: Custom Synthesis

SZ目录编号:	: SZ-A077002
CAS 号	: NA
分子式	: C27H31F2N9O
分子量	: 535.6
投资状态	: Inquire