Ledipasvir Intermediate 2

N° de SZ CAT:	SZ-L010031
Número CAS	1441670-89-8
Mol.F.	C27H26BrF2N3O2
Peso Molecular	542.4
Status de Fatura	Out of Stock

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Nome Químico: (S)-Tert-butyl 6-(5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: BrC1=CC=C(C2=CC=C(C3=CN=C([C@H]4N(C(OC(C)(C)C)=O)CC5(CC5)C4)N3)C=C2C6(F)F)C6=C1

Insights into the Dissolution Behavior of Ledipasvir-Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions
Chailu Que, Xiaochun Lou, Dmitry Y. Zemlyanov, Huaping Mo, Anura S. Indulkar, Yi Gao, Geoff G.Z. Zhang, and Lynne S. Taylor
Mol. Pharmaceutics 2019, 16, 12, 5054–5067

A green stability-indicating RP-HPLC-UV method using factorial design for determination of ribavirin, sofosbuvir and ledipasvir: Application to average content, acid degradation kinetics and in vitro drug interactions study
Hanan I.EL-ShorbagyacFawziElsebaeiaSherin F.HammadbAmina M.El-Brashy
Microchemical Journal Volume 158, November 2020, 105251

Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry
Ahmed Hemdan & Maya S. Eissa
Journal of Analytical Science and Technology volume 10, Article number: 39 (2019)

Chemometrically Assisted RP-HPLC and Spectroscopic Method Development for Simultaneous Multi-Component Analysis of Ledipasvir and Sofosbuvir in Pure and Pharmaceutical Formulation
Roma N Trivedi1* , Jinal N Tandel2 , Rashmika C Patel2 , Samir K Shah2
Der Pharmacia Lettre, 2018, 10 [3]: 62-75

Ledipasvir Intermediate 2 is chemically (S)-Tert-butyl 6-(5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl)-5-azaspiro[2.4]heptane-5-carboxylate. Ledipasvir Intermediate 2 is supplied with detailed characterization data compliant with regulatory guideline. Ledipasvir Intermediate 2 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Ledipasvir.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

N° de SZ CAT:	: SZ-L010001
Número CAS	: 1256388-51-8
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: In Stock
Rel. CAS No	: 2128695-48-5 (HCl salt)

N° de SZ CAT:	: SZ-L010029
Número CAS	: 1129634-44-1
Mol.F.	: C12H19NO4
Peso Molecular	: 241.3
Status de Fatura	: In Stock
Rel. CAS No	: 1441673-92-2 (K salt)

N° de SZ CAT:	: SZ-L010032
Número CAS	: 2128695-48-5
Mol.F.	: C49H54F2N8O6 : HCl
Peso Molecular	: 889.0 : 36.5
Status de Fatura	: Custom Synthesis
Rel. CAS No	: 1256388-51-8 (free base)

Ledipasvir Intermediate 2

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N° de SZ CAT:	: SZ-L010D01
Número CAS	: NA
Mol.F.	: C49H48D6F2N8O6
Peso Molecular	: 895.1
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010D02
Número CAS	: NA
Mol.F.	: C47H52F2N8O4
Peso Molecular	: 831.0
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010002
Número CAS	: 1256393-35-7
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010003
Número CAS	: 1256391-66-8
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-L010004
Número CAS	: NA
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010005
Número CAS	: NA
Mol.F.	: C29H29BrN4O4
Peso Molecular	: 577.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010006
Número CAS	: 2040487-43-0
Mol.F.	: C49H54N8O7
Peso Molecular	: 867.0
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010007
Número CAS	: NA
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010010
Número CAS	: 1256388-50-7
Mol.F.	: C29H29BrF2N4O3
Peso Molecular	: 599.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010013
Número CAS	: NA
Mol.F.	: C29H29BrF2N4O3
Peso Molecular	: 599.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010014
Número CAS	: NA
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010015
Número CAS	: NA
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: Limited Stock

N° de SZ CAT:	: SZ-L010016
Número CAS	: NA
Mol.F.	: C49H54F2N8O6
Peso Molecular	: 889.0
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-L010017
Número CAS	: 2705846-40-6
Mol.F.	: C18H23N3O2
Peso Molecular	: 313.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010018
Número CAS	: NA
Mol.F.	: C18H23N3O2
Peso Molecular	: 313.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010019
Número CAS	: NA
Mol.F.	: C18H23N3O2
Peso Molecular	: 313.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010020
Número CAS	: NA
Mol.F.	: C18H23N3O2
Peso Molecular	: 313.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010021
Número CAS	: 1256387-87-7
Mol.F.	: C24H34BN3O4
Peso Molecular	: 439.4
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-L010022
Número CAS	: NA
Mol.F.	: C24H34BN3O4
Peso Molecular	: 439.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010023
Número CAS	: NA
Mol.F.	: C24H34BN3O4
Peso Molecular	: 439.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-L010024
Número CAS	: NA
Mol.F.	: C24H34BN3O4
Peso Molecular	: 439.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010025
Número CAS	: 1378387-87-1
Mol.F.	: C26H37BN4O5
Peso Molecular	: 496.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010026
Número CAS	: NA
Mol.F.	: C26H37BN4O5
Peso Molecular	: 496.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010027
Número CAS	: NA
Mol.F.	: C26H37BN4O5
Peso Molecular	: 496.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010028
Número CAS	: NA
Mol.F.	: C26H37BN4O5
Peso Molecular	: 496.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-L010030
Número CAS	: 291775-59-2
Mol.F.	: C12H19NO4
Peso Molecular	: 241.3
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-L010031
Número CAS	: 1441670-89-8
Mol.F.	: C27H26BrF2N3O2
Peso Molecular	: 542.4
Status de Fatura	: Out of Stock

N° de SZ CAT:	: SZ-L010033
Número CAS	: NA
Mol.F.	: C49H53F2N9O7
Peso Molecular	: 918.0
Status de Fatura	: Inquire

N° de SZ CAT:	: SZ-L010034
Número CAS	: NA
Mol.F.	: C49H52F2N10O8
Peso Molecular	: 947.0
Status de Fatura	: Inquire

N° de SZ CAT:	: SZ-L010035
Número CAS	: NA
Mol.F.	: C49H53F2N9O7
Peso Molecular	: 918.0
Status de Fatura	: Inquire