Halobetasol Impurity 8

Quantification of halobetasol propionate and its impurities present in topical dosage forms by stability-​indicating LC method
By Nalwade, Santaji; Reddy, Vangala Ranga; Kulkarni, Dipak; Todamal, Sandip
From Journal of Chromatographic Science (2015), 53(1), 127-134
 
Impurity profiling and a stability-​indicating UPLC method development and validation for the estimation of related impurities of halobetasol propionate in halobetasol propionate 0.05​% (w​/w) cream
By Prakash, Lakkireddy; Malipeddi, H.; Subbaiah, Venkata B.; Lakka, Narasimha S.
From Journal of Chromatographic Science (2015), 53(1), 112-121
 
Spectrophotometric determination of clobetasol propionate, halobetasol propionate, quinagolide hydrochloride, through charge transfer complexation
By Mostafa Azza A; Bebawy Lories I; Refaat Heba H
From Journal of pharmaceutical and biomedical analysis (2002), 27(6), 889-99

Halobetasol Impurity 8 is chemically (6S,9R,10S,11S,13S,16S,17R)-6-Chloro-9-fluoro-11-hydroxy-10,13,16-trimethyl-17-(2-((methylsulfonyl)oxy)acetyl)-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate. Halobetasol Impurity 8 is supplied with detailed characterization data compliant with regulatory guideline. Halobetasol Impurity 8 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Halobetasol.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.