Bosentan Hydroxymethyl O-Desmethyl Impurity

N° de SZ CAT:	SZ-B017008
Número CAS	253688-62-9
Mol.F.	C26H27N5O7S
Peso Molecular	553.6
Status de Fatura	Custom Synthesis

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Nome Químico: 4-(1-Hydroxy-2-methylpropan-2-yl)-N-(6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: OC1=C(C=CC=C1)OC(C(N[S](=O)(C2=CC=C(C(C)(C)CO)C=C2)=O)=NC(C3=NC=CC=N3)=N4)=C4OCCO

Research and Development of a Second-Generation Process for Bosentan, an Endothelin Receptor Antagonist
Peter J. Harrington, Hiralal N. Khatri, Brad S. DeHoff, Martin R. Guinn, Mark A. Boehler, and Karl A. Glaser
Organic Process Research & Development 2002, 6, 120−124

Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist
Sanjay A. Jadhav,1 Shashikant B. Landge,1 Sonali L. Jadhav,1 Navanath C. Niphade,1 Saroj R. Bembalkar,2 and Vijayavitthal T. Mathad1
E-Hindawi Access to Research Chromatography Research International Volume 2011, Article ID 929876, 9 pages

Development and validation of a stability indicating analytical method for the related substances of Bosentan drug substance by HPLC
Mubeen Ahmad Khan, Sukumar Sinha, Mangesh Todkar, Vikas Parashar, K. Swamy Reddy
Am. J. Sci. Ind. Res., 2012, 3(2): 69-80

Bosentan Hydroxymethyl O-Desmethyl Impurity is chemically 4-(1-Hydroxy-2-methylpropan-2-yl)-N-(6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide. Bosentan Hydroxymethyl O-Desmethyl Impurity is supplied with detailed characterization data compliant with regulatory guideline. Bosentan Hydroxymethyl O-Desmethyl Impurity can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Bosentan.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

N° de SZ CAT:	: SZ-B017001
Número CAS	: 157212-55-0
Mol.F.	: C27H29N5O6S : H2O
Peso Molecular	: 551.6 : 18.0
Status de Fatura	: In Stock
Rel. CAS No	: 147536-97-8 (free base)

Bosentan Hydroxymethyl O-Desmethyl Impurity

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N° de SZ CAT:	: SZ-B017D01
Número CAS	: 1065472-77-6
Mol.F.	: C27H25D4N5O6S
Peso Molecular	: 555.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017002
Número CAS	: 253688-60-7
Mol.F.	: C27H29N5O7S
Peso Molecular	: 567.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017008
Número CAS	: 253688-62-9
Mol.F.	: C26H27N5O7S
Peso Molecular	: 553.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017012
Número CAS	: 1257099-41-4
Mol.F.	: C22H27N5O6S
Peso Molecular	: 489.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017021
Número CAS	: 10362-14-8
Mol.F.	: C10H16N2
Peso Molecular	: 164.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017022
Número CAS	: NA
Mol.F.	: C10H17N3
Peso Molecular	: 179.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017013
Número CAS	: 1257099-42-5
Mol.F.	: C20H21N5O4S
Peso Molecular	: 427.5
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017014
Número CAS	: 1257099-43-6
Mol.F.	: C29H33N5O7S
Peso Molecular	: 595.7
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-B017015
Número CAS	: 1257099-44-7
Mol.F.	: C27H27N5O5S
Peso Molecular	: 533.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017016
Número CAS	: 193013-72-8
Mol.F.	: C10H15NO2S
Peso Molecular	: 213.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017017
Número CAS	: NA
Mol.F.	: C15H13N5O3
Peso Molecular	: 311.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017018
Número CAS	: 174227-27-1
Mol.F.	: C17H17N5O4
Peso Molecular	: 355.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017019
Número CAS	: 157415-46-8
Mol.F.	: C26H27N5O5S
Peso Molecular	: 521.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017020
Número CAS	: 1177447-87-8
Mol.F.	: C21H23ClN4O4
Peso Molecular	: 430.9
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017009
Número CAS	: 253688-61-8
Mol.F.	: C26H27N5O6S
Peso Molecular	: 537.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017010
Número CAS	: NA
Mol.F.	: C27H29N5O4S
Peso Molecular	: 519.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017011
Número CAS	: NA
Mol.F.	: C27H29N5O5S
Peso Molecular	: 535.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017003
Número CAS	: 150727-06-3
Mol.F.	: C25H24ClN5O4S
Peso Molecular	: 526.0
Status de Fatura	: Out of Stock, Custom Synthesis

N° de SZ CAT:	: SZ-B017004
Número CAS	: 174227-14-6
Mol.F.	: C25H25N5O5S
Peso Molecular	: 507.6
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-B017005
Número CAS	: 1097263-60-9
Mol.F.	: C52H52N10O10S2
Peso Molecular	: 1041.2
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-B017006
Número CAS	: 150728-13-5
Mol.F.	: C15H10Cl2N4O2
Peso Molecular	: 349.2
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-B017007
Número CAS	: 6292-59-7
Mol.F.	: C10H15NO2S
Peso Molecular	: 213.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-B017D04
Número CAS	: NA
Mol.F.	: C2513C2H25D4N5O6S
Peso Molecular	: 557.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017D02
Número CAS	: 1065472-91-4
Mol.F.	: C27H25D4N5O7S
Peso Molecular	: 571.6
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-B017D03
Número CAS	: 1246817-57-1
Mol.F.	: C27H23D6N5O7S
Peso Molecular	: 573.7
Status de Fatura	: Custom Synthesis