Aprepitant D4

N° de SZ CAT:	SZ-A030D01
Número CAS	1133387-60-6
Mol.F.	C23H17D4F7N4O3
Peso Molecular	538.46
Status de Fatura	Custom Synthesis

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Nome Químico: 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl-2,3,5,6-d4)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Sorrisos: O=C1NC(CN(CCO2)[C@@H](C(C([2H])=C3[2H])=C(C([2H])=C3F)[2H])[C@H]2O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)=NN1

Application of analytical quality by design principles for the determination of alkyl p-toluenesulfonates impurities in Aprepitant by HPLC. Validation using total-error concept
Constantinos K. Zacharis, Elli Vastardi
Journal of Pharmaceutical and Biomedical Analysis Volume 150, 20 February 2018, Pages 152-161

Characterization and Quantitation of Aprepitant Drug Substance Polymorphs by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Roy Helmy,* George X. Zhou, Yadan W. Chen, Louis Crocker, Tao Wang, Robert M. Wenslow, Jr., and Anant Vailaya*
Anal. Chem. 2003, 75, 605-611

Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Tim Tome,†,Nina Ž igart, Zdenko Č asar,, and AlešObreza
Org. Process Res. Dev. 2019, 23, 1784−1802

Aprepitant D4 is chemically 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl-2,3,5,6-d4)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one. Aprepitant D4 is supplied with detailed characterization data compliant with regulatory guideline. Aprepitant D4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Aprepitant.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Aprepitant D4

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N° de SZ CAT:	: SZ-A030001
Número CAS	: 170729-80-3
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030002
Número CAS	: 1185502-97-9
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030003
Número CAS	: 172822-28-5
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030004
Número CAS	: 1242175-34-3
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030005
Número CAS	: 170902-81-5
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030006
Número CAS	: 1242175-40-1
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030D01
Número CAS	: 1133387-60-6
Mol.F.	: C23H17D4F7N4O3
Peso Molecular	: 538.46
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030007
Número CAS	: 170729-76-7
Mol.F.	: C23H22F6N4O3
Peso Molecular	: 516.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030008
Número CAS	: 2348441-62-1
Mol.F.	: C29H25F7N4O3
Peso Molecular	: 610.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030009
Número CAS	: 2348441-63-2
Mol.F.	: C29H25F7N4O3
Peso Molecular	: 610.5
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030031
Número CAS	: 155742-64-6
Mol.F.	: C4H8ClN3O2
Peso Molecular	: 165.6
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030041
Número CAS	: 171338-33-3
Mol.F.	: C20H19F6NO2
Peso Molecular	: 419.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030042
Número CAS	: 287930-75-0
Mol.F.	: C21H19F6NO3
Peso Molecular	: 447.4
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030043
Número CAS	: 380499-07-0
Mol.F.	: C20H16F7NO2
Peso Molecular	: 435.3
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030012
Número CAS	: 380499-06-9
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030014
Número CAS	: 1185503-48-3
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030015
Número CAS	: 170902-80-4
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030016
Número CAS	: 1242175-36-5
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030017
Número CAS	: 170729-79-0
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030018
Número CAS	: 327623-37-0
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: Out of Stock, Custom Synthesis

N° de SZ CAT:	: SZ-A030019
Número CAS	: 1242175-38-7
Mol.F.	: C20H18F7NO2
Peso Molecular	: 437.4
Status de Fatura	: In Stock

N° de SZ CAT:	: SZ-A030020
Número CAS	: 419574-33-7
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030021
Número CAS	: NA
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030022
Número CAS	: 419574-04-2
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030023
Número CAS	: NA
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030024
Número CAS	: NA
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030025
Número CAS	: 2514951-25-6
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030026
Número CAS	: NA
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030027
Número CAS	: NA
Mol.F.	: C20H16F7NO3
Peso Molecular	: 451.3
Status de Fatura	: Custom Synthesis

N° de SZ CAT:	: SZ-A030028
Número CAS	: 172676-88-9
Mol.F.	: C23H21F7N4O3
Peso Molecular	: 534.4
Status de Fatura	: Custom Synthesis