Abemaciclib D8

SZ CAT No:	SZ-A077D01
CAS No	2088650-53-5
Mol.F.	C27H24D8F2N8
Mol.Wt.	514.7
Inv. Status	Custom Synthesis

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Chemical Name: N-(5-((4-Ethylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CC(N1C2=CC(C3=NC(NC4=CC=C(CN5C([2H])([2H])C([2H])([2H])N(CC)C([2H])([2H])C5([2H])[2H])C=N4)=NC=C3F)=CC(F)=C2N=C1C)C

Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry
By Martinez-Chavez, Alejandra; Rosing, Hilde; Hillebrand, Michel; Tibben, Matthijs; Schinkel, Alfred H.; Beijnen, Jos H.
From Analytical and Bioanalytical Chemistry (2019), 411(20), 5331-5345

Abemaciclib D8 is chemically N-(5-((4-Ethylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine. Abemaciclib D8 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib D8 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Abemaciclib D8

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SZ CAT No:	: SZ-A077001
CAS No	: 1231929-97-7
Mol.F.	: C27H32F2N8
Mol.Wt.	: 506.6
Inv. Status	: In Stock

SZ CAT No:	: SZ-A077D02
CAS No	: 2088650-71-7
Mol.F.	: C27H22D10F2N8
Mol.Wt.	: 516.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077D03
CAS No	: 1809251-51-1
Mol.F.	: C27H27D5F2N8
Mol.Wt.	: 511.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077D04
CAS No	: NA
Mol.F.	: C27H25D7F2N8
Mol.Wt.	: 513.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077D01
CAS No	: 2088650-53-5
Mol.F.	: C27H24D8F2N8
Mol.Wt.	: 514.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077003
CAS No	: 1180132-17-5
Mol.F.	: C12H20N4
Mol.Wt.	: 220.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077005
CAS No	: 1231930-42-9
Mol.F.	: C15H13ClF2N4
Mol.Wt.	: 322.7
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077006
CAS No	: 414881-11-1
Mol.F.	: C12H19N3
Mol.Wt.	: 205.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-A077007
CAS No	: NA
Mol.F.	: C27H33FN8
Mol.Wt.	: 488.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077008
CAS No	: NA
Mol.F.	: C15H14F2N4
Mol.Wt.	: 288.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077004
CAS No	: 1231930-57-6
Mol.F.	: C25H28F2N8
Mol.Wt.	: 478.6
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-A077002
CAS No	: NA
Mol.F.	: C27H31F2N9O
Mol.Wt.	: 535.6
Inv. Status	: Inquire

Abemaciclib D8

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