Macitentan D4

SZ CAT No:	SZ-M044D01
CAS No	1258428-05-5
Mol.F.	C19H16D4Br2N6O4S
Mol.Wt.	592.3
Inv. Status	Custom Synthesis

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Chemical Name: N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-Sulfamided4

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=[S](NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)(NCCC)=O

Macitentan D4 is chemically N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-Sulfamided4. Macitentan D4 is supplied with detailed characterization data compliant with regulatory guideline. Macitentan D4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Macitentan.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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SZ CAT No:	: SZ-M044001
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N-Despropyl Macitentan

SZ CAT No:	: SZ-M044002
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Macitentan Dimer Impurity

SZ CAT No:	: SZ-M044003
CAS No	: 2089065-77-8
Mol.F.	: C28H32Br2N8O6S2
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O-Desbromo-Pyrimidinyl Macitentan

SZ CAT No:	: SZ-M044004
CAS No	: 1393813-43-8
Mol.F.	: C15H19BrN4O4S
Mol.Wt.	: 431.3
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Rel. CAS No	: 1393813-43-8 (K salt) ; 2760252-50-2 (Na salt)

Macitentan Pyrimidine Amine Impurity

SZ CAT No:	: SZ-M044005
CAS No	: 1393813-42-7
Mol.F.	: C13H14BrClN4O2S
Mol.Wt.	: 405.7
Inv. Status	: In Stock

Despropylaminosulfonyl Macitentan

SZ CAT No:	: SZ-M044006
CAS No	: 1433875-21-8
Mol.F.	: C16H13Br2N5O2
Mol.Wt.	: 467.1
Inv. Status	: In Stock

Macitentan Impurity 2

SZ CAT No:	: SZ-M044007
CAS No	: 2211054-90-7
Mol.F.	: C10H8Br2N4O2
Mol.Wt.	: 376.0
Inv. Status	: In Stock

Macitentan Impurity 3

SZ CAT No:	: SZ-M044008
CAS No	: NA
Mol.F.	: C19H20Cl2N6O4S
Mol.Wt.	: 499.4
Inv. Status	: In Stock

N-Despropyl-N-Methyl Macitentan

SZ CAT No:	: SZ-M044009
CAS No	: 441798-25-0
Mol.F.	: C17H16Br2N6O4S
Mol.Wt.	: 560.2
Inv. Status	: In Stock

N-Despropyl-N-Ethyl Macitentan

SZ CAT No:	: SZ-M044010
CAS No	: 441796-13-0
Mol.F.	: C18H18Br2N6O4S
Mol.Wt.	: 574.3
Inv. Status	: In Stock

Macitentan Impurity 7

SZ CAT No:	: SZ-M044011
CAS No	: 1433875-14-9
Mol.F.	: C15H17BrN4O5S
Mol.Wt.	: 445.3
Inv. Status	: Custom Synthesis

S-Despropylamino S-Methyl Macitentan

SZ CAT No:	: SZ-M044012
CAS No	: 556796-88-4
Mol.F.	: C17H15Br2N5O4S
Mol.Wt.	: 545.2
Inv. Status	: Custom Synthesis

Macitentan Impurity 9

SZ CAT No:	: SZ-M044013
CAS No	: 2518002-08-7
Mol.F.	: C11H8BrClN2O
Mol.Wt.	: 299.6
Inv. Status	: Custom Synthesis

Macitentan Impurity 10

SZ CAT No:	: SZ-M044014
CAS No	: NA
Mol.F.	: C14H16BrN3O
Mol.Wt.	: 322.2
Inv. Status	: Custom Synthesis

Macitentan Impurity 11

SZ CAT No:	: SZ-M044015
CAS No	: 2108101-97-7
Mol.F.	: C16H23BrN6O4S2
Mol.Wt.	: 507.4
Inv. Status	: Custom Synthesis

Macitentan Impurity 12

SZ CAT No:	: SZ-M044016
CAS No	: 1642873-04-8
Mol.F.	: C12H10BrClN2O2
Mol.Wt.	: 329.6
Inv. Status	: In Stock

Macitentan Impurity 4

SZ CAT No:	: SZ-M044017
CAS No	: NA
Mol.F.	: C15H18BrN3O2
Mol.Wt.	: 352.2
Inv. Status	: Custom Synthesis

Pyrimidine N-Propyl Impurity

SZ CAT No:	: SZ-M044019
CAS No	: NA
Mol.F.	: C19H19Br2N5O2
Mol.Wt.	: 509.2
Inv. Status	: In Stock

Macitentan Impurity 13

SZ CAT No:	: SZ-M044020
CAS No	: 3974-18-3
Mol.F.	: C10H5Cl3N2
Mol.Wt.	: 259.5
Inv. Status	: In Stock

Macitentan Impurity 14

SZ CAT No:	: SZ-M044021
CAS No	: 2211059-05-9
Mol.F.	: C12H12BrN3O2
Mol.Wt.	: 310.2
Inv. Status	: In Stock

5-Des-Bromo-Macitentan

SZ CAT No:	: SZ-M044022
CAS No	: 2211059-00-4
Mol.F.	: C19H21BrN6O4S
Mol.Wt.	: 509.4
Inv. Status	: In Stock

Macitentan Impurity 16

SZ CAT No:	: SZ-M044023
CAS No	: 2211054-17-8
Mol.F.	: C12H10BrN3O
Mol.Wt.	: 292.1
Inv. Status	: In Stock

Macitentan Impurity 17

SZ CAT No:	: SZ-M044024
CAS No	: 2211054-46-3
Mol.F.	: C10H8BrN3O
Mol.Wt.	: 266.1
Inv. Status	: In Stock

Macitentan Impurity 18

SZ CAT No:	: SZ-M044025
CAS No	: NA
Mol.F.	: C17H19BrN2O3S
Mol.Wt.	: 411.3
Inv. Status	: Custom Synthesis

Macitentan D4

SZ CAT No:	: SZ-M044D01
CAS No	: 1258428-05-5
Mol.F.	: C19H16D4Br2N6O4S
Mol.Wt.	: 592.3
Inv. Status	: Custom Synthesis

Macitentan Impurity 19

SZ CAT No:	: SZ-M044026
CAS No	: NA
Mol.F.	: C13H14BrClN4O2S
Mol.Wt.	: 405.7
Inv. Status	: Custom Synthesis

Macitentan Impurity 20

SZ CAT No:	: SZ-M044027
CAS No	: NA
Mol.F.	: C10H6BrClN2O
Mol.Wt.	: 285.5
Inv. Status	: In Stock

Macitentan Stage-I Hydroxy Impurity

SZ CAT No:	: SZ-M044029
CAS No	: 2365406-85-3
Mol.F.	: C13H15BrN4O3S
Mol.Wt.	: 387.3
Inv. Status	: In Stock

Macitentan KSM-I Impurity

SZ CAT No:	: SZ-M044030
CAS No	: 146533-41-7
Mol.F.	: C10H5BrCl2N2
Mol.Wt.	: 304.0
Inv. Status	: In Stock, 3-4 days for Dispatch

Macitentan KSM-III Impurity

SZ CAT No:	: SZ-M044031
CAS No	: 32779-36-5
Mol.F.	: C4H2BrClN2
Mol.Wt.	: 193.4
Inv. Status	: In Stock, 3-4 days for Dispatch

Macitentan 4-Chloro Analog

SZ CAT No:	: SZ-M044018
CAS No	: 441798-36-3
Mol.F.	: C19H20BrClN6O4S
Mol.Wt.	: 543.8
Inv. Status	: In Stock

Macitentan Impurity 21

SZ CAT No:	: SZ-M044032
CAS No	: 441797-83-7
Mol.F.	: C12H12BrClN4O2S
Mol.Wt.	: 391.7
Inv. Status	: In Stock

Macitentan Impurity 22

SZ CAT No:	: SZ-M044033
CAS No	: NA
Mol.F.	: C20H21Cl2N5O4S
Mol.Wt.	: 498.4
Inv. Status	: Custom Synthesis

Chlordisulfurylisocyanat

SZ CAT No:	: SZ-M044028
CAS No	: 63549-29-1
Mol.F.	: CClNO6S2
Mol.Wt.	: 221.6
Inv. Status	: Custom Synthesis

Macitentan Isopropyl Impurity

SZ CAT No:	: SZ-M044034
CAS No	: NA
Mol.F.	: C19H20Br2N6O4S
Mol.Wt.	: 588.3
Inv. Status	: In Stock

N-Nitroso Macitentan

SZ CAT No:	: SZ-M044035
CAS No	: NA
Mol.F.	: C19H19Br2N7O5S
Mol.Wt.	: 617.3
Inv. Status	: Inquire

N-Nitroso Ethylene hydroxy Impurity

SZ CAT No:	: SZ-M044036
CAS No	: NA
Mol.F.	: C15H18BrN5O5S
Mol.Wt.	: 460.3
Inv. Status	: Inquire

N-Nitroso Macitentan Dimer Impurity

SZ CAT No:	: SZ-M044037
CAS No	: NA
Mol.F.	: C28H30Br2N10O8S2
Mol.Wt.	: 858.5
Inv. Status	: Inquire

N-Nitroso Pyrimidine Amine Impurity

SZ CAT No:	: SZ-M044038
CAS No	: NA
Mol.F.	: C13H13BrClN5O3S
Mol.Wt.	: 434.7
Inv. Status	: Inquire

Macitentan D4

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