Tretinoin EP Impurity A

Development and validation of analytical spectrophotometric and RP-​HPLC methods for the simultaneous estimation of hydroquinone, hydrocortisone and tretinoin ternary mixture in topical formulation
By Al Jamal, Marwa K.; Gazy, Azza A.
From International Journal of Pharmacy and Pharmaceutical Sciences (2019), 11(11), 10-16
 
Stability indicating simultaneous validation of azelaic acid, minoxidil and tretinoin with forced degradation behavior study by RP-​HPLC in pharmaceutical dosage form
By Sharma, Akhilesh; Mishra, Anurag; Sharma, Sanjay
From European Journal of Biomedical and Pharmaceutical Sciences (2016), 3(11), 272-281
 

Tretinoin EP Impurity A is chemically (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid (as per EP). It is also known as Isotretinoin ; 13-cis-Retinoic Acid ; 13-cis-β-Retinoic acid ; 13-cis-Vitamin A acid ; Isotrex. Tretinoin EP Impurity A is supplied with detailed characterization data compliant with regulatory guideline. Tretinoin EP Impurity A can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tretinoin.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.