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Ticagrelor Impurity 78

SZ CAT No SZ-T023162
CAS No NA
Mol.F. C26H31F2N7O5S : HCl
Mol.Wt. 591.6 : 36.5
Inv. Status In Stock
Related CAS No 2476859-56-8 (free base)


Chemical Name: N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(3-((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)nitrous amide hydrochloride

Four process-related potential new impurities in ticagrelor: Identification, isolation, characterization using HPLC, LC/ESI–MSn, NMR and their synthesis
NeerajKumaraSubba RaoDevineniaPrasad ReddyGajjalaaDharmendra KumarGuptaaSandeshBhataRajeshKumarbShailendra KumarDubeyaPramodKumar
Journal of Pharmaceutical and Biomedical Analysis 120 (2016) 248–260
 
Solubility Measurement and Mathematical Correlation of Ticagrelor in Different Pure Solvents
Ke Chen, Yixin Zhang, and Jianping Ge
J. Chem. Eng. Data 2020, 65, 7, 3560–3565
 
An efficient and safe process for the preparation of ticagrelor, a platelet aggregation inhibitor via resin‑NO2 catalyzed formation of triazole ring
Gorakshanath B. Shinde1, Pravin K. Mahale1, Santhosh A. Padaki1, Navnath C. Niphade1, Raghunath B. Toche2 and Vijayavitthal T. Mathad
Shinde et al. SpringerPlus  (2015) 4:493
 
Ultra-fast liquid chromatography method for the determination of ticagrelor in pharmaceutical formulations and spiked plasma samples
Cem Önal 1* and Ş. Evrim Kepekçi Tekkeli
J. Chem. Metrol. 13:2 (2019) 39-46

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