Ketoconazole EP Impurity D

SZ CAT No:	SZ-K001005
CAS No	67914-61-8
Mol.F.	C24H26Cl2N4O3
Mol.Wt.	489.4
Inv. Status	In Stock

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Chemical Name: 1-[4-[[(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine (as per EP)

Synonym: N-Desacetyl Ketoconazole

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: ClC(C=C1)=CC(Cl)=C1[C@](OC2)(CN3C=CN=C3)O[C@H]2COC(C=C4)=CC=C4N5CCNCC5

Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis–mass spectrometry
Mar´ıa Castro-Puyana a, Carmen Garc´ıa-Ruiz a, Alejandro Cifuentes b, Antonio L. Crego a, Maria Luisa Marina
Journal of Chromatography A, 1114 (2006) 170–177

Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor
Aneta Grycová , Aneta Dořičáková 1, Zdeněk Dvořák
Toxicol Lett . 2015 Dec 3;239(2):67-72

Ion-pairing liquid chromatographic method determination of ketoconazole and stress degradation in pharmaceutical formulations with fluorescence detection
Wisanu Thongchai
Brazilian Journal of Pharmaceutical Sciences Sci. vol.56

Development and Validation of Stability-Indicating Method for the Simultaneous Determination of Ketoconazole and Beauvericin in Pharmaceutical Tablets
Tingting Tian, Min Yang, Zhongxi Zhao, Yuxia Luan, Xuan Tang, Meihua Zhu, Yan Liu
Journal of Chromatographic Science, Volume 54, Issue 3, 1 March 2016, Pages 361–366

Ketoconazole EP Impurity D is chemically 1-[4-[[(2RS,4SR)-2-(2,4-Dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine (as per EP). It is also known as N-Desacetyl Ketoconazole. Ketoconazole EP Impurity D is supplied with detailed characterization data compliant with regulatory guideline. Ketoconazole EP Impurity D can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Ketoconazole.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

Ketoconazole EP Impurity D

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SZ CAT No:	: SZ-K001001
CAS No	: 65277-42-1
Mol.F.	: C26H28Cl2N4O4
Mol.Wt.	: 531.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001002
CAS No	: 254912-63-5
Mol.F.	: C26H26Cl2N4O4
Mol.Wt.	: 529.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001003
CAS No	: 1346598-39-7
Mol.F.	: C38H42Cl2N6O6
Mol.Wt.	: 749.7
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001004
CAS No	: 83374-59-8
Mol.F.	: C26H28Cl2N4O4
Mol.Wt.	: 531.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001005
CAS No	: 67914-61-8
Mol.F.	: C24H26Cl2N4O3
Mol.Wt.	: 489.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001006
CAS No	: 134071-44-6
Mol.F.	: C21H20Cl2N2O5S
Mol.Wt.	: 483.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001007
CAS No	: 170210-42-1
Mol.F.	: C14H14Cl2N2O3
Mol.Wt.	: 329.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001008
CAS No	: 254912-65-7
Mol.F.	: C26H28Cl2N4O5
Mol.Wt.	: 547.4
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001009
CAS No	: 98-59-9
Mol.F.	: C7H7ClO2S
Mol.Wt.	: 190.7
Inv. Status	: In Stock, 3-4 days for Dispatch

SZ CAT No:	: SZ-K001010
CAS No	: 372-18-9
Mol.F.	: C6H4F2
Mol.Wt.	: 114.1
Inv. Status	: In Stock, 3-4 days for Dispatch

SZ CAT No:	: SZ-K001011
CAS No	: 581806-59-9
Mol.F.	: C12H14N2O2
Mol.Wt.	: 218.3
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001012
CAS No	: NA
Mol.F.	: C26H26Cl2N4O4
Mol.Wt.	: 529.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001013
CAS No	: 170210-49-8
Mol.F.	: C14H14Cl2N2O3
Mol.Wt.	: 329.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001014
CAS No	: 170210-39-6
Mol.F.	: C18H15BrCl2O4
Mol.Wt.	: 446.1
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001015
CAS No	: 2234-16-4
Mol.F.	: C8H6Cl2O
Mol.Wt.	: 189.0
Inv. Status	: In Stock, 3-4 days for Dispatch

SZ CAT No:	: SZ-K001016
CAS No	: 1610851-14-3
Mol.F.	: C21H20Cl2N2O5S
Mol.Wt.	: 483.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001019
CAS No	: NA
Mol.F.	: C14H14Cl2N2O3
Mol.Wt.	: 329.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001020
CAS No	: 61441-65-4
Mol.F.	: C14H14Cl2N2O3
Mol.Wt.	: 329.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001021
CAS No	: 67914-60-7
Mol.F.	: C12H16N2O2
Mol.Wt.	: 220.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001022
CAS No	: 84682-23-5
Mol.F.	: C14H14Cl2N2O3
Mol.Wt.	: 329.2
Inv. Status	: In Stock

Ketoconazole EP Impurity D

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SZ CAT No:	: SZ-K001023
CAS No	: 170210-46-5
Mol.F.	: C18H15BrCl2O4
Mol.Wt.	: 446.1
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001025
CAS No	: 170210-50-1
Mol.F.	: C15H16Cl2N2O5S
Mol.Wt.	: 407.3
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001D01
CAS No	: 1217766-70-5
Mol.F.	: C26H25D3Cl2N4O4
Mol.Wt.	: 534.5
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001D02
CAS No	: 1217706-96-1
Mol.F.	: C26H20D8Cl2N4O4
Mol.Wt.	: 539.5
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001026
CAS No	: NA
Mol.F.	: C26H28Cl2N4O7S
Mol.Wt.	: 611.5
Inv. Status	: Under Synthesis

SZ CAT No:	: SZ-K001017
CAS No	: 2095256-87-2
Mol.F.	: C21H20Cl2N2O5S
Mol.Wt.	: 483.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001028
CAS No	: 61397-58-8
Mol.F.	: C14H14Cl2N2O3
Mol.Wt.	: 329.2
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001018
CAS No	: NA
Mol.F.	: C26H26Cl2N4O5
Mol.Wt.	: 545.4
Inv. Status	: Custom Synthesis

SZ CAT No:	: SZ-K001029
CAS No	: 1334423-12-9
Mol.F.	: C26H29ClN4O4
Mol.Wt.	: 497.0
Inv. Status	: In Stock

SZ CAT No:	: SZ-K001030
CAS No	: 98405-42-6
Mol.F.	: C23H25BrCl2N2O4
Mol.Wt.	: 544.3
Inv. Status	: In Stock