Hydrocortisone EP Impurity H

SZ CAT No:	SZ-H008009
CAS No	NA
Mol.F.	C21H30O6
Mol.Wt.	378.5
Inv. Status	Limited Stock

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Chemical Name: 7α,11β,17,21-Tetrahydroxypregn-4-ene-3,20-dione

Synonym: 7α-hydroxyhydrocortisone

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O[C@]1(C(CO)=O)CC[C@]2([H])[C@@]1(C[C@]([C@]3([C@]2([C@]([H])(O)CC4=CC(CC[C@]34C)=O)[H])[H])([H])O)C

Comparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities
Fawzia Ibrahim a , Asmaa Kamal El-Deen a,b , Kuniyoshi Shimizu
Journal of Food and Drug Analysis Volume 26, Issue 3, July 2018, Pages 1160-1170

Novel stability indicating UHPLC method development and validation for simultaneous quantification of hydrocortisone acetate, pramoxine hydrochloride, potassium sorbate and sorbic acid in topical cream formulation
Lakshmi Narasimha RaoKatakamaThirupathiDongalabSanthosh KumarEttaboina
Talanta Open Volume 1, August 2020, 100004

Novel eco-friendly chromatographic determinations of hydrocortisone acetate, fusidic acid, their pharmacologically active impurities and pharmaceutical excipients: a comparative study
Maha M. Abdelrahman, Raghda Abdelmoneim Emam, Nouruddin W. Ali & Eglal A. Abdelaleem
Chemical Papers volume 74, pages2175–2187(2020)

An RP-HPLC Method for the Stability-Indicating Analysis of Impurities of Both Fusidic Acid and Betamethasone-17-Valerate in a Semi-Solid Pharmaceutical Dosage Form
Jonathan Byrne, Trinidad Velasco-Torrijos, Robert Reinhardt
Journal of Chromatographic Science, Volume 53, Issue 9, October 2015, Pages 1498–1503

Analytical method development and determination of hydrocortisone acetate and fusidic acid simultaneously in cream formulation, by reversed‐phase HPLC
Nawaz Rasool, Qudsia Kanwal, Muhammad Waseem
Biomedical Chromatography Volume35, Issue3 March 2021 e4997

Hydrocortisone EP Impurity H is chemically 7α,11β,17,21-Tetrahydroxypregn-4-ene-3,20-dione . It is also known as 7α-hydroxyhydrocortisone. Hydrocortisone EP Impurity H is supplied with detailed characterization data compliant with regulatory guideline. Hydrocortisone EP Impurity H can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Hydrocortisone.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Hydrocortisone

SZ CAT No:	: SZ-H008001
CAS No	: 50-23-7
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity A

SZ CAT No:	: SZ-H008002
CAS No	: 50-24-8
Mol.F.	: C21H28O5
Mol.Wt.	: 360.4
Inv. Status	: In Stock

Hydrocortisone EP Impurity B

SZ CAT No:	: SZ-H008003
CAS No	: 53-06-5
Mol.F.	: C21H28O5
Mol.Wt.	: 360.4
Inv. Status	: In Stock

Hydrocortisone EP Impurity C

SZ CAT No:	: SZ-H008004
CAS No	: 50-03-3
Mol.F.	: C23H32O6
Mol.Wt.	: 404.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity D

SZ CAT No:	: SZ-H008005
CAS No	: 53-35-0
Mol.F.	: C21H30O6
Mol.Wt.	: 378.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity E

SZ CAT No:	: SZ-H008006
CAS No	: 600-99-7
Mol.F.	: C21H28O5
Mol.Wt.	: 360.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity F

SZ CAT No:	: SZ-H008007
CAS No	: 152-58-9
Mol.F.	: C21H30O4
Mol.Wt.	: 346.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity G

SZ CAT No:	: SZ-H008008
CAS No	: 14760-49-7
Mol.F.	: C21H28O5
Mol.Wt.	: 360.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity H

SZ CAT No:	: SZ-H008009
CAS No	: NA
Mol.F.	: C21H30O6
Mol.Wt.	: 378.5
Inv. Status	: Limited Stock

Hydrocortisone EP Impurity I

SZ CAT No:	: SZ-H008010
CAS No	: 103795-84-2
Mol.F.	: C21H30O6
Mol.Wt.	: 378.5
Inv. Status	: Custom Synthesis

Hydrocortisone EP Impurity J

SZ CAT No:	: SZ-H008011
CAS No	: 16463-74-4
Mol.F.	: C23H32O6
Mol.Wt.	: 404.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity K

SZ CAT No:	: SZ-H008012
CAS No	: 640-87-9
Mol.F.	: C23H32O5
Mol.Wt.	: 388.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity L

SZ CAT No:	: SZ-H008013
CAS No	: 641-77-0
Mol.F.	: C21H30O4
Mol.Wt.	: 346.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity M

SZ CAT No:	: SZ-H008014
CAS No	: 566-35-8
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: In Stock

Hydrocortisone EP Impurity N

SZ CAT No:	: SZ-H008015
CAS No	: NA
Mol.F.	: C42H58O10
Mol.Wt.	: 722.9
Inv. Status	: In Stock

Hydrocortisone EP Impurity O

SZ CAT No:	: SZ-H008016
CAS No	: 154032-37-8
Mol.F.	: C21H30O6
Mol.Wt.	: 378.5
Inv. Status	: Custom Synthesis

6-Alpha Methyl Hydrocortisone

SZ CAT No:	: SZ-H008017
CAS No	: 1625-39-4
Mol.F.	: C22H32O5
Mol.Wt.	: 376.5
Inv. Status	: In Stock

Hydrocortisone 17-21 Orthoester

SZ CAT No:	: SZ-H008018
CAS No	: 13609-63-7
Mol.F.	: C26H38O6
Mol.Wt.	: 446.6
Inv. Status	: Out of Stock

Hydrocortisone-21-Butyrate

SZ CAT No:	: SZ-H008019
CAS No	: 6677-99-2
Mol.F.	: C25H36O6
Mol.Wt.	: 432.6
Inv. Status	: Out of Stock

6α-Hydroxy Cortisol

SZ CAT No:	: SZ-H008020
CAS No	: 2242-98-0
Mol.F.	: C21H30O6
Mol.Wt.	: 378.5
Inv. Status	: In Stock

Hydrocortisone (9b,11b)-Epoxide

SZ CAT No:	: SZ-H008021
CAS No	: 10072-97-6
Mol.F.	: C21H28O5
Mol.Wt.	: 360.5
Inv. Status	: In Stock

Cortisone Succinate Sodium Salt

SZ CAT No:	: SZ-H008022
CAS No	: 7415-42-1
Mol.F.	: C25H31O8 : Na
Mol.Wt.	: 459.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 10215-75-5 (free base)

Hydrocortisone Impurity A

SZ CAT No:	: SZ-H008023
CAS No	: 103228-51-9
Mol.F.	: C25H33O8 : Na
Mol.Wt.	: 461.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 103242-89-3 (free base)

Hydrocortisone Impurity B

SZ CAT No:	: SZ-H008024
CAS No	: 105562-12-7
Mol.F.	: C21H28O4
Mol.Wt.	: 344.5
Inv. Status	: In Stock

Hydrocortisone Impurity C

SZ CAT No:	: SZ-H008025
CAS No	: 105562-13-8
Mol.F.	: C21H28O4
Mol.Wt.	: 344.5
Inv. Status	: In Stock

Hydrocortisone Impurity D (Na)

SZ CAT No:	: SZ-H008026
CAS No	: 70795-33-4
Mol.F.	: C25H33O7 : Na
Mol.Wt.	: 445.5 : 23.0
Inv. Status	: In Stock
Rel. CAS No	: 3331-69-9 (free base)

Hydrocortisone 17-Succinate

SZ CAT No:	: SZ-H008027
CAS No	: 220489-73-6
Mol.F.	: C25H34O8
Mol.Wt.	: 462.5
Inv. Status	: Limited Stock

Hydrocortisone Sodium Phosphate

SZ CAT No:	: SZ-H008028
CAS No	: 6000-74-4
Mol.F.	: C21H29O8P2 : 2(Na)
Mol.Wt.	: 440.4 : 2(23.0)
Inv. Status	: In Stock
Rel. CAS No	: 3863-59-0 (free base)

Hydrocortisone-21-Valerate

SZ CAT No:	: SZ-H008029
CAS No	: 6678-00-8
Mol.F.	: C26H38O6
Mol.Wt.	: 446.6
Inv. Status	: Custom Synthesis

Prednisolone-21-Valerate

SZ CAT No:	: SZ-H008031
CAS No	: 39791-31-6
Mol.F.	: C26H36O6
Mol.Wt.	: 444.6
Inv. Status	: In Stock

Hydrocortisone Acetate EP Impurity C

SZ CAT No:	: SZ-H008032
CAS No	: 52-21-1
Mol.F.	: C23H30O6
Mol.Wt.	: 402.5
Inv. Status	: In Stock

Hydrocortisone Acetate EP Impurity D

SZ CAT No:	: SZ-H008033
CAS No	: 50-04-4
Mol.F.	: C23H30O6
Mol.Wt.	: 402.5
Inv. Status	: In Stock

Hydrocortisone Acetate EP Impurity E

SZ CAT No:	: SZ-H008034
CAS No	: 7753-60-8
Mol.F.	: C23H30O5
Mol.Wt.	: 386.5
Inv. Status	: In Stock

Hydrocortisone Acetate EP Impurity F

SZ CAT No:	: SZ-H008035
CAS No	: 1250-97-1
Mol.F.	: C23H32O6
Mol.Wt.	: 404.5
Inv. Status	: In Stock

Hydrocortisone Acetate EP Impurity G

SZ CAT No:	: SZ-H008036
CAS No	: 81968-66-3
Mol.F.	: C25H34O7
Mol.Wt.	: 446.5
Inv. Status	: In Stock

Hydrocortisone Glyoxal Hydrate Isomer 1

SZ CAT No:	: SZ-H008037
CAS No	: 1960421-03-7
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: In Stock
Rel. CAT No	: SZ-C191002 ,

Hydrocortisone Glyoxal Hydrate Isomer 2

SZ CAT No:	: SZ-H008038
CAS No	: NA
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: Custom Synthesis

11-β-Hydroxyandrostenedione

SZ CAT No:	: SZ-H008039
CAS No	: 382-44-5
Mol.F.	: C19H26O3
Mol.Wt.	: 302.4
Inv. Status	: In Stock

Hydrocortisone Oxo Acetic Acid

SZ CAT No:	: SZ-H008041
CAS No	: 33762-00-4
Mol.F.	: C21H28O5
Mol.Wt.	: 360.5
Inv. Status	: In Stock

Hydrocortisone Impurity E

SZ CAT No:	: SZ-H008042
CAS No	: NA
Mol.F.	: C25H39NO7
Mol.Wt.	: 465.6
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity F

SZ CAT No:	: SZ-H008043
CAS No	: NA
Mol.F.	: C22H32O5
Mol.Wt.	: 376.5
Inv. Status	: Out of Stock, Custom Synthesis

Hydrocortisone Impurity G

SZ CAT No:	: SZ-H008044
CAS No	: NA
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: In Stock

Hydrocortisone Impurity H

SZ CAT No:	: SZ-H008045
CAS No	: 2394-25-4
Mol.F.	: C20H28O4
Mol.Wt.	: 332.4
Inv. Status	: Limited Stock

Hydrocortisone D4

SZ CAT No:	: SZ-H008D01
CAS No	: 73565-87-4
Mol.F.	: C21H26D4O5
Mol.Wt.	: 366.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 1

SZ CAT No:	: SZ-H008046
CAS No	: NA
Mol.F.	: C29H44O7
Mol.Wt.	: 504.7
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 2

SZ CAT No:	: SZ-H008047
CAS No	: NA
Mol.F.	: C29H44O7
Mol.Wt.	: 504.7
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 3

SZ CAT No:	: SZ-H008048
CAS No	: NA
Mol.F.	: C10H18O5
Mol.Wt.	: 218.2
Inv. Status	: Custom Synthesis

Hydrocortisone Valerate Impurity 3

SZ CAT No:	: SZ-H008049
CAS No	: NA
Mol.F.	: C26H36O7
Mol.Wt.	: 460.6
Inv. Status	: Custom Synthesis

9α-Bromohydrocortisone Acetate

SZ CAT No:	: SZ-H008050
CAS No	: 50733-54-5
Mol.F.	: C23H31BrO6
Mol.Wt.	: 483.4
Inv. Status	: In Stock

Δ9(11)-Hydrocortisone 17-Valerate

SZ CAT No:	: SZ-H008051
CAS No	: NA
Mol.F.	: C26H36O5
Mol.Wt.	: 428.6
Inv. Status	: In Stock

Hydrocortisone Un-Symmetrical Dimer

SZ CAT No:	: SZ-H008052
CAS No	: NA
Mol.F.	: C42H58O9
Mol.Wt.	: 706.9
Inv. Status	: In Stock

Cortisone 21-Hemisuccinate

SZ CAT No:	: SZ-H008053
CAS No	: 10215-75-5
Mol.F.	: C25H32O8
Mol.Wt.	: 460.5
Inv. Status	: In Stock
Rel. CAS No	: 7415-42-1 (Na salt)

Hydrocortisone Hemisuccinate

SZ CAT No:	: SZ-H008054
CAS No	: 2203-97-6
Mol.F.	: C25H34O8
Mol.Wt.	: 462.5
Inv. Status	: In Stock
Rel. CAS No	: 83784-20-7 (hydrate salt)

∆6 Hydrocortisone Hemisuccinate

SZ CAT No:	: SZ-H008055
CAS No	: NA
Mol.F.	: C25H32O8
Mol.Wt.	: 460.5
Inv. Status	: In Stock

Cortienic Acid

SZ CAT No:	: SZ-H008056
CAS No	: 3597-45-3
Mol.F.	: C20H28O5
Mol.Wt.	: 348.4
Inv. Status	: In Stock

Hydrocortisone Cortienyl Aldehyde Impurity

SZ CAT No:	: SZ-H008057
CAS No	: NA
Mol.F.	: C20H28O4
Mol.Wt.	: 332.4
Inv. Status	: In Stock

6α-Hydroxy-11-Deoxycortisol

SZ CAT No:	: SZ-H008058
CAS No	: 76941-54-3
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 4

SZ CAT No:	: SZ-H008060
CAS No	: 97154-36-4
Mol.F.	: C24H32O6
Mol.Wt.	: 416.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 6

SZ CAT No:	: SZ-H008062
CAS No	: NA
Mol.F.	: C23H28O6
Mol.Wt.	: 400.5
Inv. Status	: Custom Synthesis

21-Deoxy Cortisone

SZ CAT No:	: SZ-H008063
CAS No	: 1882-82-2
Mol.F.	: C21H28O4
Mol.Wt.	: 344.5
Inv. Status	: Custom Synthesis

9 Alpha Hydroxyl Hydrocortisone Acetate

SZ CAT No:	: SZ-H008064
CAS No	: 50733-56-7
Mol.F.	: C23H32O7
Mol.Wt.	: 420.5
Inv. Status	: In Stock

3-Enol Ether Cortisone Acetate

SZ CAT No:	: SZ-H008065
CAS No	: 1852-65-9
Mol.F.	: C25H34O6
Mol.Wt.	: 430.5
Inv. Status	: In Stock

Delta 6,7 Cortisone Acetate

SZ CAT No:	: SZ-H008066
CAS No	: 2435-02-1
Mol.F.	: C23H28O6
Mol.Wt.	: 400.5
Inv. Status	: In Stock

Delta 8,9 Cortisone Acetate

SZ CAT No:	: SZ-H008067
CAS No	: 1856-26-4
Mol.F.	: C23H28O6
Mol.Wt.	: 400.5
Inv. Status	: Custom Synthesis

Hydrocortisone 17-Butyrate 3-Enol Methyl Ether

SZ CAT No:	: SZ-H008068
CAS No	: NA
Mol.F.	: C26H38O6
Mol.Wt.	: 446.6
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 7

SZ CAT No:	: SZ-H008069
CAS No	: NA
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 8

SZ CAT No:	: SZ-H008070
CAS No	: NA
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 9

SZ CAT No:	: SZ-H008071
CAS No	: 103497-66-1
Mol.F.	: C25H32O7
Mol.Wt.	: 444.5
Inv. Status	: In Stock
Rel. CAS No	: 103228-47-3 (Na salt)

Hydrocortisone Impurity 10

SZ CAT No:	: SZ-H008072
CAS No	: NA
Mol.F.	: C25H32O7
Mol.Wt.	: 444.5
Inv. Status	: Out of Stock

Hydrocortisone Caproate

SZ CAT No:	: SZ-H008073
CAS No	: 3593-96-2
Mol.F.	: C27H40O6
Mol.Wt.	: 460.6
Inv. Status	: In Stock

17-Dehydro-21-Hydroxy Hydrocortisone

SZ CAT No:	: SZ-H008074
CAS No	: 68473-77-8
Mol.F.	: C21H30O6
Mol.Wt.	: 378.5
Inv. Status	: In Stock

Hydrocortisone Impurity 12

SZ CAT No:	: SZ-H008076
CAS No	: NA
Mol.F.	: C23H28O6
Mol.Wt.	: 400.5
Inv. Status	: In Stock

Hydrocortisone Impurity 13

SZ CAT No:	: SZ-H008077
CAS No	: NA
Mol.F.	: C21H28O6
Mol.Wt.	: 376.4
Inv. Status	: In Stock

21-Dehydrocortisone

SZ CAT No:	: SZ-H008078
CAS No	: 16574-04-2
Mol.F.	: C21H26O5
Mol.Wt.	: 358.4
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 15

SZ CAT No:	: SZ-H008079
CAS No	: 3597-44-2
Mol.F.	: C20H26O5
Mol.Wt.	: 346.4
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 16

SZ CAT No:	: SZ-H008080
CAS No	: 2601-23-2
Mol.F.	: C23H26O6
Mol.Wt.	: 398.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 17

SZ CAT No:	: SZ-H008081
CAS No	: 27149-67-3
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 18

SZ CAT No:	: SZ-H008082
CAS No	: 27149-68-4
Mol.F.	: C21H30O5
Mol.Wt.	: 362.5
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 19

SZ CAT No:	: SZ-H008083
CAS No	: 10184-70-0
Mol.F.	: C21H28O4
Mol.Wt.	: 344.5
Inv. Status	: In Stock

Hydrocortisone Impurity D

SZ CAT No:	: SZ-H008084
CAS No	: 3331-69-9
Mol.F.	: C25H34O7
Mol.Wt.	: 446.5
Inv. Status	: Out of Stock
Rel. CAS No	: 70795-33-4 (Na salt)

Hydrocortisone Impurity 20

SZ CAT No:	: SZ-H008085
CAS No	: 65208-85-7
Mol.F.	: C21H29ClO4
Mol.Wt.	: 380.9
Inv. Status	: In Stock

Hydrocortisone Impurity 21

SZ CAT No:	: SZ-H008086
CAS No	: 4383-30-6
Mol.F.	: C23H30O6
Mol.Wt.	: 402.5
Inv. Status	: In Stock

6-β-Hydroxycortisol-d4

SZ CAT No:	: SZ-H008D02
CAS No	: 1261254-51-6
Mol.F.	: C21H26D4O6
Mol.Wt.	: 382.5
Inv. Status	: Custom Synthesis

Hydrocortisone 17-phosphate

SZ CAT No:	: SZ-H008087
CAS No	: 220489-76-9
Mol.F.	: C21H31O8P
Mol.Wt.	: 442.4
Inv. Status	: Custom Synthesis

6-Beta Hydroxy Hydrocortisone Phosphate

SZ CAT No:	: SZ-H008088
CAS No	: NA
Mol.F.	: C21H31O9P
Mol.Wt.	: 458.4
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 23

SZ CAT No:	: SZ-H008089
CAS No	: NA
Mol.F.	: C20H28O5
Mol.Wt.	: 348.4
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 24

SZ CAT No:	: SZ-H008090
CAS No	: NA
Mol.F.	: C21H29O7P
Mol.Wt.	: 424.4
Inv. Status	: In Stock

Hydrocortisone 21-phosphate

SZ CAT No:	: SZ-H008091
CAS No	: 3863-59-0
Mol.F.	: C21H31O8P
Mol.Wt.	: 442.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 6000-74-4 (2Na salt) ; 38048-30-5 (Na salt)

Hydrocortisone 21-Carboxylic Acid

SZ CAT No:	: SZ-H008092
CAS No	: 57172-48-2
Mol.F.	: C21H28O6
Mol.Wt.	: 376.4
Inv. Status	: In Stock

Hydrocortisone Impurity 25

SZ CAT No:	: SZ-H008093
CAS No	: NA
Mol.F.	: C23H30O6
Mol.Wt.	: 402.5
Inv. Status	: Custom Synthesis

21-Chloro Hydrocortisone

SZ CAT No:	: SZ-H008094
CAS No	: 75868-48-3
Mol.F.	: C21H27ClO3
Mol.Wt.	: 362.9
Inv. Status	: Custom Synthesis

Epi Hydrocortisone Hemisuccinate

SZ CAT No:	: SZ-H008095
CAS No	: 103242-89-3
Mol.F.	: C25H34O8
Mol.Wt.	: 462.5
Inv. Status	: In Stock
Rel. CAS No	: 103228-51-9 (Na salt)

Hydrocortisone Butyrate

SZ CAT No:	: SZ-H008096
CAS No	: 13609-67-1
Mol.F.	: C25H36O6
Mol.Wt.	: 432.6
Inv. Status	: Custom Synthesis

Hydrocortisone Impurity 26

SZ CAT No:	: SZ-H008097
CAS No	: 2427-65-8
Mol.F.	: C21H24O5
Mol.Wt.	: 356.4
Inv. Status	: Custom Synthesis

Hydrocortisone EP Impurity H

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