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Cefalexin EP Impurity B Hydrochloride

SZ CAT No SZ-C018018
CAS No 111696-41-4
Mol.F. C8H10N2O3S : HCl
Mol.Wt. 214.2 : 36.5
Inv. Status Custom Synthesis
Same As SZ-C061035,
Rel. CAS No 22252-43-3 (free base) ; 56871-82-0 (Na salt)


Chemical Name: (6R,7R)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Hydrochloride (as per EP)

Synonym: 7-Aminodesacetoxycephalosporanic acid ; 7-ADCA

Multidimensional evaluation of impurity profiles for generic cephalexin and cefaclor antibiotics
B.A. Olsen*, S.W. Baertschi and R.M. Riggin
Journal of Chromatography, 648 (1993) 165-173
 
Chemistry of Cephalosporin Antibiotics. XIII. Ilesac-etoxycephalosporins. The Synthesis of Cephalexin' and Soine Analogs
Charles W. Ryan, R. L. Simon, and Earle M. Van Heyningen
J. Med. Chem. 1969, 12, 2, 310–313
 
Stress Studies and Identification of Degradation Products of Cephalexin Using LC–PDA and LC–MS/MS
V. T. Gawande, K. G. Bothara & A. M. Marathe
Chromatographia volume 80, pages1545–1552(2017)