Atracurium Impurity M (R-cis, R'-cis)-Atracurium Free base

SZ CAT No:	SZ-A021074
CAS No	1193104-84-5
Mol.F.	C54H74N2O12
Mol.Wt.	943.2
Inv. Status	Custom Synthesis
Rel. CAS No	1193104-85-6 (besylate salt)

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Chemical Name: (1R,1'R,2S,2'S)-2,2'-((hexane-1,6-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium)

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C(OCCCCCCOC(CC[N@@+]1(C)CCC(C=C(OC)C(OC)=C2)=C2[C@H]1CC3=CC=C(OC)C(OC)=C3)=O)CC[N@+]4(C)[C@H](CC5=CC=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4

Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection
Agata Błazewicz, Zbigniew Fijałeka,b, Małgorzata Warowna-Grzeskiewicz ,Magdalena Jadach
Journal of Chromatography A, 1217 (2010) 1266–1272

Directly Coupled Chiral HPLC-NMR and HPLC-CD Spectroscopy as Complementary Methods for Structural and Enantiomeric Isomer Identification: Application to Atracurium Besylate
Nisha Mistry,Andrew D. Roberts, George E. Tranter,Peter Francis, Ian Barylski, Ismail M. Ismail,§ Jeremy K. Nicholson,| and John C. Lindon
Anal. Chem. 1999, 71, 2838-2843

Atracurium Impurity M (R-cis, R'-cis)-Atracurium Free base is chemically (1R,1'R,2S,2'S)-2,2'-((hexane-1,6-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium). Atracurium Impurity M (R-cis, R'-cis)-Atracurium Free base is supplied with detailed characterization data compliant with regulatory guideline. Atracurium Impurity M (R-cis, R'-cis)-Atracurium Free base can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Atracurium.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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(R)-cis-5ξ-Methyl Atracurium Dibesylate

SZ CAT No:	: SZ-A021034
CAS No	: 1193104-82-3
Mol.F.	: C54H74N2O12 : 2(C6H5O3S)
Mol.Wt.	: 943.2 : 2(157.2)
Inv. Status	: In Stock

(R)-trans-Atracurium Besylate

SZ CAT No:	: SZ-A021033
CAS No	: 96946-46-2
Mol.F.	: C53H72N2O12 : 2(C6H5O3S)
Mol.Wt.	: 929.2 : 2(157.2)
Inv. Status	: Custom Synthesis

(R-cis, R'-trans)- Atracurium Chloride

SZ CAT No:	: SZ-A021008
CAS No	: NA
Mol.F.	: C53H72N2O12 : 2(Cl)
Mol.Wt.	: 929.2 : 2(35.5)
Inv. Status	: In Stock

(R-cis, R'-trans)-Atracurium

SZ CAT No:	: SZ-A021050
CAS No	: 96946-43-9
Mol.F.	: C53H72N2O12
Mol.Wt.	: 929.2
Inv. Status	: Custom Synthesis

(R-trans, R'-trans)-Atracurium

SZ CAT No:	: SZ-A021069
CAS No	: 96946-45-1
Mol.F.	: C53H72N2O12
Mol.Wt.	: 929.2
Inv. Status	: Custom Synthesis

(R-trans, R'-trans)-Atracurium Trifluoro acetate

SZ CAT No:	: SZ-A021007
CAS No	: NA
Mol.F.	: C53H72N2O12 : 2(C2F3O2)
Mol.Wt.	: 929.2 : 2(113.0)
Inv. Status	: Out of Stock, Custom Synthesis

Atracurium

SZ CAT No:	: SZ-A021065
CAS No	: 64228-79-1
Mol.F.	: C53H72N2O12
Mol.Wt.	: 929.2
Inv. Status	: Custom Synthesis

Atracurium Impurity 7

SZ CAT No:	: SZ-A021079
CAS No	: NA
Mol.F.	: C53H72N2O12
Mol.Wt.	: 929.2
Inv. Status	: Custom Synthesis

Atracurium Besilate

SZ CAT No:	: SZ-A021001
CAS No	: 64228-81-5
Mol.F.	: C53H72N2O12 : 2(C6H5O3S)
Mol.Wt.	: 157.2 : 2(157.2)
Inv. Status	: In Stock

Atracurium Besilate EP Impurity A

SZ CAT No:	: SZ-A021043
CAS No	: 155913-36-3
Mol.F.	: C52H69N2O12 : C6H5O3S
Mol.Wt.	: 914.1 : 157.2
Inv. Status	: In Stock

Atracurium Besilate Impurity 4

SZ CAT No:	: SZ-A021027
CAS No	: NA
Mol.F.	: C32H44NO8 : C6H5O3S
Mol.Wt.	: 570.7 : 157.2
Inv. Status	: Custom Synthesis

Atracurium Besilate EP Impurity C (Mixture of Diastereomers)

SZ CAT No:	: SZ-A021016
CAS No	: NA
Mol.F.	: C32H44NO8 : C6H5O3S
Mol.Wt.	: 570.7 : 157.2
Inv. Status	: In Stock

Atracurium Besilate Impurity C2 Iodide

SZ CAT No:	: SZ-A021012
CAS No	: NA
Mol.F.	: C32H44NO8 : I
Mol.Wt.	: 570.7 : 126.9
Inv. Status	: Custom Synthesis

Atracurium Impurity 9 (Besylate salt)

SZ CAT No:	: SZ-A021023
CAS No	: 1075726-90-7
Mol.F.	: C25H34NO6 : C6H5O3S
Mol.Wt.	: 444.5 : 157.2
Inv. Status	: In Stock

Atracurium EP Impurity K (Besylate salt)

SZ CAT No:	: SZ-A021015
CAS No	: NA
Mol.F.	: C54H74N2O12 : 2(C6H5O3S)
Mol.Wt.	: 943.2 : 2(157.2)
Inv. Status	: In Stock

Atracurium Besylate EP Impurity B

SZ CAT No:	: SZ-A021031
CAS No	: 64228-77-9
Mol.F.	: C51H66N2O12
Mol.Wt.	: 899.1
Inv. Status	: In Stock

Atracurium EP impurity C (TFA salt)

SZ CAT No:	: SZ-A021036
CAS No	: NA
Mol.F.	: C32H44NO8 : C2HF3O2
Mol.Wt.	: 570.7 : 114.0
Inv. Status	: In Stock

Atracurium EP Impurity D (TFA salt)

SZ CAT No:	: SZ-A021041
CAS No	: NA
Mol.F.	: C29H42NO7 : C2F3O2
Mol.Wt.	: 516.7 : 113.0
Inv. Status	: In Stock

Atracurium Besylate Impurity D2 Iodide (cis-Quaternary Alcohol)

SZ CAT No:	: SZ-A021005
CAS No	: NA
Mol.F.	: C29H42NO7 : I
Mol.Wt.	: 516.7 : 126.9
Inv. Status	: Custom Synthesis

Atracurium cis-Quaternary Acid

SZ CAT No:	: SZ-A021060
CAS No	: 1075727-06-8
Mol.F.	: C24H32NO6 : C6H5O3S
Mol.Wt.	: 430.5 : 157.2
Inv. Status	: In Stock

Atracurium cis-Quaternary methyl ester (Besylate)

SZ CAT No:	: SZ-A021049
CAS No	: 1075726-88-3
Mol.F.	: C25H34NO6 : C6H5O3S
Mol.Wt.	: 444.5 : 157.2
Inv. Status	: In Stock

Atracurium EP Impurity A (TFA salt)

SZ CAT No:	: SZ-A021093
CAS No	: NA
Mol.F.	: C52H69N2O12 : C2F3O2
Mol.Wt.	: 914.1 : 113.0
Inv. Status	: In Stock

Cisatracurium EP Impurity R (Oxalate salt)

SZ CAT No:	: SZ-A021053
CAS No	: 96687-52-4
Mol.F.	: C51H66N2O12 : 2C2H2O4
Mol.Wt.	: 899.1 : 2(90.0)
Inv. Status	: In Stock

Atracurium EP impurity C

SZ CAT No:	: SZ-A021088
CAS No	: 86293-35-8
Mol.F.	: C32H44NO8
Mol.Wt.	: 570.7
Inv. Status	: Custom Synthesis

Atracurium EP Impurity D (Mixture of Diastereomers)

SZ CAT No:	: SZ-A021077
CAS No	: 87046-72-8
Mol.F.	: C29H42NO7
Mol.Wt.	: 516.4
Inv. Status	: Custom Synthesis

Atracurium EP Impurity D Iodide (Mixture of Diastereomers)

SZ CAT No:	: SZ-A021017
CAS No	: NA
Mol.F.	: C29H42NO7 : I
Mol.Wt.	: 516.7 : 126.9
Inv. Status	: Custom Synthesis

Atracurium EP Impurity E (Dihydrate)

SZ CAT No:	: SZ-A021055
CAS No	: NA
Mol.F.	: C24H32NO6 : 2(H2O)
Mol.Wt.	: 430.5 : 2(18.0)
Inv. Status	: Out of Stock

Atracurium EP Impurity F (Besylate salt)

SZ CAT No:	: SZ-A021056
CAS No	: 155913-37-4
Mol.F.	: C22H30NO4 : C6H5O3S
Mol.Wt.	: 372.5 : 157.2
Inv. Status	: In Stock

Atracurium EP impurity G

SZ CAT No:	: SZ-A021032
CAS No	: 1699-51-0
Mol.F.	: C21H27NO4
Mol.Wt.	: 357.5
Inv. Status	: In Stock

Atracurium EP impurity G Hydrochloride

SZ CAT No:	: SZ-A021063
CAS No	: 37545-26-9
Mol.F.	: C21H27NO4 : HCl
Mol.Wt.	: 357.5 : 36.5
Inv. Status	: In Stock

Atracurium EP Impurity H

SZ CAT No:	: SZ-A021057
CAS No	: NA
Mol.F.	: C54H74N2O12
Mol.Wt.	: 943.2
Inv. Status	: Custom Synthesis

Atracurium EP Impurity I (Besylate salt)

SZ CAT No:	: SZ-A021058
CAS No	: NA
Mol.F.	: C54H74N2O12 : 2(C6H5O3S)
Mol.Wt.	: 943.2 : 2(157.2)
Inv. Status	: In Stock

Atracurium EP Impurity J

SZ CAT No:	: SZ-A021059
CAS No	: 80-18-2
Mol.F.	: C7H8O3S
Mol.Wt.	: 172.2
Inv. Status	: In Stock

Atracurium EP impurity K

SZ CAT No:	: SZ-A021096
CAS No	: 2767988-79-2
Mol.F.	: C54H74N2O12
Mol.Wt.	: 943.2
Inv. Status	: Custom Synthesis

(R)-N-Methyllaudanosine Iodide

SZ CAT No:	: SZ-A021024
CAS No	: 41431-32-7
Mol.F.	: C22H30NO4 : I
Mol.Wt.	: 372.5 : 126.9
Inv. Status	: In Stock

Atracurium Impurity 15

SZ CAT No:	: SZ-A021054
CAS No	: 86682-55-5
Mol.F.	: C20H25NO5
Mol.Wt.	: 359.4
Inv. Status	: Custom Synthesis

Atracurium Impurity 16

SZ CAT No:	: SZ-A021064
CAS No	: 20345-69-1
Mol.F.	: C20H21NO5
Mol.Wt.	: 355.4
Inv. Status	: In Stock

Atracurium Impurity 2 (Iodide salt)

SZ CAT No:	: SZ-A021025
CAS No	: NA
Mol.F.	: C56H76N2O14 : 2(I)
Mol.Wt.	: 1001.2 : 2(126.9)
Inv. Status	: Custom Synthesis

Atracurium Impurity 2

SZ CAT No:	: SZ-A021084
CAS No	: NA
Mol.F.	: C56H76N2O14
Mol.Wt.	: 1001.2
Inv. Status	: Custom Synthesis

(R)-cis-5ξ-Methyl Atracurium TFA salt

SZ CAT No:	: SZ-A021026
CAS No	: NA
Mol.F.	: C54H74N2O122 : 2(C2F3O2)
Mol.Wt.	: 943.2 : 2(113.0)
Inv. Status	: In Stock

Atracurium Impurity 4

SZ CAT No:	: SZ-A021086
CAS No	: NA
Mol.F.	: C32H44NO8
Mol.Wt.	: 570.7
Inv. Status	: Custom Synthesis

R-Tetrahydropapaverine

SZ CAT No:	: SZ-A021028
CAS No	: 876290-45-8
Mol.F.	: C20H25NO4 : C11H13NO3
Mol.Wt.	: 343.4 : 207.2
Inv. Status	: In Stock

(R)-(+)-Tetrahydropapaverine

SZ CAT No:	: SZ-A021030
CAS No	: 50896-90-7
Mol.F.	: C20H25NO4
Mol.Wt.	: 343.4
Inv. Status	: In Stock

Atracurium Impurity 8 (cis-Quaternary Alcohol)

SZ CAT No:	: SZ-A021042
CAS No	: NA
Mol.F.	: C29H42NO7 : C2F3O2
Mol.Wt.	: 516.7 : 113.0
Inv. Status	: In Stock

Atracurium Impurity 8 (Trans-Quaternary Alcohol)

SZ CAT No:	: SZ-A021029
CAS No	: NA
Mol.F.	: C29H42NO7 : Cl
Mol.Wt.	: 516.7 : 35.5
Inv. Status	: Out of Stock

Atracurium Impurity A1 (trans-Monoquatenary)

SZ CAT No:	: SZ-A021009
CAS No	: NA
Mol.F.	: C52H69N2O12 : C2F3O2
Mol.Wt.	: 914.1 : 113.0
Inv. Status	: Out of Stock, Custom Synthesis

Atracurium Impurity A1 (trans-Monoquatenary) Free base

SZ CAT No:	: SZ-A021070
CAS No	: 2024603-91-4
Mol.F.	: C52H69N2O12
Mol.Wt.	: 914.1
Inv. Status	: Custom Synthesis

Atracurium Impurity A2 (cis-Monoquatenary)

SZ CAT No:	: SZ-A021071
CAS No	: NA
Mol.F.	: C52H69N2O12
Mol.Wt.	: 914.1
Inv. Status	: Custom Synthesis

Atracurium Impurity A2 (cis-Monoquatenary) TFA salt

SZ CAT No:	: SZ-A021010
CAS No	: NA
Mol.F.	: C52H69N2O12 : C2F3O2
Mol.Wt.	: 914.1 : 113.0
Inv. Status	: In Stock

Atracurium Impurity C1 (trans-Monoacrylate)

SZ CAT No:	: SZ-A021072
CAS No	: NA
Mol.F.	: C32H44NO8
Mol.Wt.	: 570.7
Inv. Status	: Custom Synthesis

Atracurium Impurity C1 (trans-Monoacrylate) TFA salt

SZ CAT No:	: SZ-A021011
CAS No	: NA
Mol.F.	: C32H44NO8 : C2F3O2
Mol.Wt.	: 570.7 : 113.0
Inv. Status	: In Stock

Atracurium Impurity C

SZ CAT No:	: SZ-A021078
CAS No	: 119403-01-9
Mol.F.	: C32H44NO8
Mol.Wt.	: 570.7
Inv. Status	: Custom Synthesis

Atracurium Impurity C (Iodide salt)

SZ CAT No:	: SZ-A021018
CAS No	: NA
Mol.F.	: C32H44NO8 : I
Mol.Wt.	: 570.7 : 126.9
Inv. Status	: Custom Synthesis

Atracurium Impurity C2

SZ CAT No:	: SZ-A021073
CAS No	: NA
Mol.F.	: C32H44NO8
Mol.Wt.	: 570.7
Inv. Status	: Custom Synthesis

Atracurium Impurity D1

SZ CAT No:	: SZ-A021066
CAS No	: 2922251-87-2
Mol.F.	: C29H42NO7
Mol.Wt.	: 516.7
Inv. Status	: Custom Synthesis

Atracurium Impurity D1 (Iodide salt)

SZ CAT No:	: SZ-A021003
CAS No	: NA
Mol.F.	: C29H42NO7 : I
Mol.Wt.	: 516.7 : 126.9
Inv. Status	: Custom Synthesis

Atracurium Impurity D2 (cis-Quaternary Alcohol)

SZ CAT No:	: SZ-A021068
CAS No	: 1100676-15-0
Mol.F.	: C29H42NO7
Mol.Wt.	: 516.7
Inv. Status	: Custom Synthesis

Atracurium Impurity E (cis-Quaternary Acid) TFA salt

SZ CAT No:	: SZ-A021004
CAS No	: NA
Mol.F.	: C24H32NO6 : C2F3O2
Mol.Wt.	: 430.5 : 113.0
Inv. Status	: In Stock

(R)-Laudanosine

SZ CAT No:	: SZ-A021006
CAS No	: 85-63-2
Mol.F.	: C21H27NO4
Mol.Wt.	: 357.5
Inv. Status	: In Stock

Atracurium Impurity M ((R-cis, R'-cis)-Atracurium)

SZ CAT No:	: SZ-A021013
CAS No	: NA
Mol.F.	: C54H74N2O12 : 2(C2F3O2)
Mol.Wt.	: 943.2 : 2(113.0)
Inv. Status	: In Stock

Atracurium Impurity M (R-cis, R'-cis)-Atracurium Free base

SZ CAT No:	: SZ-A021074
CAS No	: 1193104-84-5
Mol.F.	: C54H74N2O12
Mol.Wt.	: 943.2
Inv. Status	: Custom Synthesis

Atracurium Impurity 9

SZ CAT No:	: SZ-A021083
CAS No	: 1075726-89-4
Mol.F.	: C25H34NO6
Mol.Wt.	: 444.5
Inv. Status	: Custom Synthesis

Atracurium Impurity 7 (Iodide salt)

SZ CAT No:	: SZ-A021019
CAS No	: NA
Mol.F.	: C53H72N2O12 : 2(I)
Mol.Wt.	: 929.2 : 2(126.9)
Inv. Status	: Custom Synthesis

Atracurium EP impurity K (2TFA salt)

SZ CAT No:	: SZ-A021075
CAS No	: NA
Mol.F.	: C54H74N2O12 : 2(C2F3O2)
Mol.Wt.	: 943.2 : 2(113.0)
Inv. Status	: In Stock

Bisacrylate

SZ CAT No:	: SZ-A021061
CAS No	: 36840-85-4
Mol.F.	: C11H16O4
Mol.Wt.	: 212.2
Inv. Status	: In Stock

Cis- Trans Atracurium Quaternary acid

SZ CAT No:	: SZ-A021092
CAS No	: 172589-37-6
Mol.F.	: C24H32NO6
Mol.Wt.	: 430.5
Inv. Status	: Custom Synthesis

Cis- Trans Atracurium Quaternary acid Trifluoroacetate salt

SZ CAT No:	: SZ-A021040
CAS No	: NA
Mol.F.	: C24H32NO6 : C2F3O2
Mol.Wt.	: 430.5 : 113.0
Inv. Status	: Limited Stock

Cis, Trans-R,R Atracurium Besyl

SZ CAT No:	: SZ-A021062
CAS No	: NA
Mol.F.	: C52H70N2O12 : 2(C6H6O3S)
Mol.Wt.	: 915.1 : 2(158.2)
Inv. Status	: Custom Synthesis

Atracurium cis-Quaternary methyl ester

SZ CAT No:	: SZ-A021090
CAS No	: 1075726-87-2
Mol.F.	: C25H34NO6
Mol.Wt.	: 444.5
Inv. Status	: Custom Synthesis

Atracurium cis-Quaternary methyl ester (Chloride)

SZ CAT No:	: SZ-A021038
CAS No	: NA
Mol.F.	: C25H34NO6 : Cl
Mol.Wt.	: 444.5 : 35.5
Inv. Status	: Out of Stock

Cisatracurium EP Impurity K TFA salt

SZ CAT No:	: SZ-A021014
CAS No	: NA
Mol.F.	: C54H74N2O12 : 2(C2F3O2)
Mol.Wt.	: 943.2 : 2(113.0)
Inv. Status	: In Stock

Cis-Atracurium Trifluoroacetate

SZ CAT No:	: SZ-A021002
CAS No	: NA
Mol.F.	: C53H72N2O12 : 2(C2F3O2)
Mol.Wt.	: 929.2 : 2(113.0)
Inv. Status	: In Stock

N-Desmethyl-transatracurium Besylate

SZ CAT No:	: SZ-A021035
CAS No	: 2024603-92-5
Mol.F.	: C52H69N2O12 : C6H5O3S
Mol.Wt.	: 914.1 : 157.2
Inv. Status	: Under Synthesis

Trans Atracurium Quaternary acid

SZ CAT No:	: SZ-A021091
CAS No	: NA
Mol.F.	: C24H32NO6
Mol.Wt.	: 430.5
Inv. Status	: Custom Synthesis

Trans Atracurium Quaternary acid Trifluoroacetate salt

SZ CAT No:	: SZ-A021039
CAS No	: NA
Mol.F.	: C24H32NO6 : C2F3O2
Mol.Wt.	: 430.5 : 113.0
Inv. Status	: Out of Stock

Trans Atracurium Quaternary methyl ester

SZ CAT No:	: SZ-A021089
CAS No	: 1474022-37-1
Mol.F.	: C25H34NO6
Mol.Wt.	: 444.6
Inv. Status	: Custom Synthesis

Trans Atracurium Quaternary methyl ester Trifluoroacetate salt

SZ CAT No:	: SZ-A021037
CAS No	: NA
Mol.F.	: C25H34NO6 : C2F3O2
Mol.Wt.	: 444.6 : 113.0
Inv. Status	: Out of Stock

Atracurium Impurity M (R-cis, R'-cis)-Atracurium Free base

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