Aripiprazole Di-N-Oxide

SZ CAT No:	SZ-A001023
CAS No	573691-13-1
Mol.F.	C23H27Cl2N3O4
Mol.Wt.	480.4
Inv. Status	Custom Synthesis

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Chemical Name: 7-[4-[4-(2,3-Dichlorophenyl)-1,4-dioxido-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone;

Synonym: Aripiprazole N,N-Dioxide;

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: O=C1NC2=C(C=CC(OCCCC[N+]3([O-])CC[N+](C4=CC=CC(Cl)=C4Cl)([O-])CC3)=C2)CC1

Formulation of aripiprazole-loaded pH-modulated solid dispersions via hot-melt extrusion technology: In vitro and In vivo studies
Haley McFall1 , Sandeep Sarabu1 , Vijaykumar Shankar1 , Suresh Bandari1 , S. Narasimha Murthy1 , Karl Kolter2 , Nigel Langley3 , Dong Wuk Kim4**, Michael A. Repka
International Journal of Pharmaceutics Volume 554, 10 January 2019, Pages 302-311

Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole
Carmen Klein Herenbrink, Ravi Verma, Herman D Lim, Anitha Kopinathan, Alastair Keen, Jeremy Shonberg, Christopher J. Draper-Joyce, Peter J. Scammells, Arthur Christopoulos, Jonathan A Javitch, Ben Capuano, Lei Shi, and J Robert Lane
ACS Chem. Biol. 2019, 14, 8, 1780–1792

Identification of Degradation Impurities in Aripiprazole Oral Solution Using LC-MS and Development of Validated Stability Indicating Method for Assay and Content of Two Preservatives by RP-HPLC
M. V. V. N. Murali Krishna, Sumathi V. Rao & N. V. S. Venugopal
European Journal of Chemistry 2010, 1(1), 20-27

Development of stability indicating, validated HPLC method for quantitative determination of Aripiprazole and its impurities
Nandini R. Pai*, Deepnandan S. Dubhashi
Der Pharmacia Lettre, 2010, 2(4): 1-10

Aripiprazole Di-N-Oxide is chemically 7-[4-[4-(2,3-Dichlorophenyl)-1,4-dioxido-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone;. It is also known as Aripiprazole N,N-Dioxide; . Aripiprazole Di-N-Oxide is supplied with detailed characterization data compliant with regulatory guideline. Aripiprazole Di-N-Oxide can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Aripiprazole.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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SZ CAT No:	: SZ-A001050
CAS No	: 19313-87-2
Mol.F.	: C10H12ClNO2
Mol.Wt.	: 213.7
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5-(4-Bromobutoxy)-3,4-dihydroquinolin-2(1H)-one

SZ CAT No:	: SZ-A001031
CAS No	: 63309-35-3
Mol.F.	: C13H16BrNO2
Mol.Wt.	: 298.2
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Aripiprazole

SZ CAT No:	: SZ-A001001
CAS No	: 129722-12-9
Mol.F.	: C23H27Cl2N3O2
Mol.Wt.	: 448.4
Inv. Status	: In Stock

Aripiprazole 3,4-Dichloro Impurity

SZ CAT No:	: SZ-A001015
CAS No	: 203395-75-9
Mol.F.	: C23H27Cl2N3O2
Mol.Wt.	: 448.4
Inv. Status	: In Stock

Aripiprazole 3,4-Dichlorophenyl Piperazine Impurity

SZ CAT No:	: SZ-A001016
CAS No	: 57260-67-0
Mol.F.	: C10H12Cl2N2
Mol.Wt.	: 231.1
Inv. Status	: Custom Synthesis
Rel. CAS No	: 88138-89-0 (HCl salt) ; 110407-25-5 (HBr salt) ; 876132-14-8 (Oxalate salt)

Aripiprazole Bromobutoxyquinoline Impurity

SZ CAT No:	: SZ-A001012
CAS No	: 129722-34-5
Mol.F.	: C13H16BrNO2
Mol.Wt.	: 298.2
Inv. Status	: In Stock

Aripiprazole Butanoic Acid Impurity

SZ CAT No:	: SZ-A001017
CAS No	: 58899-27-7
Mol.F.	: C13H15NO4
Mol.Wt.	: 249.3
Inv. Status	: In Stock

Aripiprazole D8

SZ CAT No:	: SZ-A001D01
CAS No	: 1089115-04-7
Mol.F.	: C23H19D8Cl2N3O2
Mol.Wt.	: 456.4
Inv. Status	: Custom Synthesis

Aripiprazole Desethylene Impurity

SZ CAT No:	: SZ-A001022
CAS No	: 1216394-63-6
Mol.F.	: C21H25Cl2N3O2
Mol.Wt.	: 422.3
Inv. Status	: Custom Synthesis

Aripiprazole Di-N-Oxide

SZ CAT No:	: SZ-A001023
CAS No	: 573691-13-1
Mol.F.	: C23H27Cl2N3O4
Mol.Wt.	: 480.4
Inv. Status	: Custom Synthesis

Aripiprazole Diquinoline Butanediol Impurity

SZ CAT No:	: SZ-A001014
CAS No	: 882880-12-8
Mol.F.	: C22H24N2O4
Mol.Wt.	: 380.4
Inv. Status	: In Stock

Aripiprazole EP Impurity A

SZ CAT No:	: SZ-A001002
CAS No	: 22246-18-0
Mol.F.	: C9H9NO2
Mol.Wt.	: 163.2
Inv. Status	: In Stock

Aripiprazole EP Impurity B

SZ CAT No:	: SZ-A001003
CAS No	: 119532-26-2
Mol.F.	: C10H12Cl2N2 : HCl
Mol.Wt.	: 231.1 : 36.5
Inv. Status	: In Stock
Rel. CAS No	: 41202-77-1 (free base)

Aripiprazole EP Impurity C

SZ CAT No:	: SZ-A001004
CAS No	: 203395-81-7
Mol.F.	: C23H28ClN3O2
Mol.Wt.	: 413.9
Inv. Status	: In Stock

Aripiprazole EP Impurity D

SZ CAT No:	: SZ-A001005
CAS No	: 203395-82-8
Mol.F.	: C23H28ClN3O2
Mol.Wt.	: 413.9
Inv. Status	: In Stock

Aripiprazole EP Impurity E

SZ CAT No:	: SZ-A001006
CAS No	: 129722-25-4
Mol.F.	: C23H25Cl2N3O2
Mol.Wt.	: 446.4
Inv. Status	: In Stock
Rel. CAS No	: 1428331-96-7 (hydrate) ; 2389989-55-1 (2HCl salt)

Aripiprazole EP Impurity F

SZ CAT No:	: SZ-A001007
CAS No	: 573691-09-5
Mol.F.	: C23H27Cl2N3O3
Mol.Wt.	: 464.4
Inv. Status	: Limited Stock

Aripiprazole EP Impurity G

SZ CAT No:	: SZ-A001008
CAS No	: 1797986-18-5
Mol.F.	: C48H56Cl4N6O4
Mol.Wt.	: 922.8
Inv. Status	: In Stock

Aripiprazole Hydroxybutyl Impurity

SZ CAT No:	: SZ-A001025
CAS No	: 870765-38-1
Mol.F.	: C14H20Cl2N2O
Mol.Wt.	: 303.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1797132-04-7 (HCl salt)

Aripiprazole Impurity 1

SZ CAT No:	: SZ-A001026
CAS No	: 17641-08-6
Mol.F.	: C9H10ClNO2
Mol.Wt.	: 199.6
Inv. Status	: In Stock
Rel. CAS No	: 861797-39-9 (HCl salt)

Aripiprazole Isomer

SZ CAT No:	: SZ-A001040
CAS No	: 203395-78-2
Mol.F.	: C23H27Cl2N3O2
Mol.Wt.	: 448.4
Inv. Status	: In Stock

Aripiprazole Impurity 11

SZ CAT No:	: SZ-A001041
CAS No	: 2748381-51-1
Mol.F.	: C24H30Cl4N4
Mol.Wt.	: 516.4
Inv. Status	: Limited Stock

Aripiprazole Spiro Analog

SZ CAT No:	: SZ-A001042
CAS No	: 795313-24-5
Mol.F.	: C14H19Cl2N2 : Br
Mol.Wt.	: 286.2 : 80
Inv. Status	: In Stock
Rel. CAS No	: 795313-25-6 (free base)

Aripiprazole Impurity 14

SZ CAT No:	: SZ-A001043
CAS No	: 30389-33-4
Mol.F.	: C9H9NO2
Mol.Wt.	: 163.2
Inv. Status	: In Stock
Rel. CAS No	: 1822761-64-7 (sodium salt)

Aripiprazole Impurity 15

SZ CAT No:	: SZ-A001044
CAS No	: 2250243-33-3
Mol.F.	: C12H13Cl2NO3
Mol.Wt.	: 290.2
Inv. Status	: In Stock

Aripiprazole Impurity 18

SZ CAT No:	: SZ-A001045
CAS No	: 2250242-47-6
Mol.F.	: C27H33Cl2N3O3
Mol.Wt.	: 518.5
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 19

SZ CAT No:	: SZ-A001046
CAS No	: 2748533-17-5
Mol.F.	: C23H29Cl2N3O2
Mol.Wt.	: 450.4
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 2

SZ CAT No:	: SZ-A001032
CAS No	: 1424857-93-1
Mol.F.	: C14H18Cl2N2
Mol.Wt.	: 285.2
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 21

SZ CAT No:	: SZ-A001047
CAS No	: 771-19-7
Mol.F.	: C9H9NO2
Mol.Wt.	: 163.2
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 23

SZ CAT No:	: SZ-A001048
CAS No	: NA
Mol.F.	: C36H43BrCl2N4O4
Mol.Wt.	: 746.6
Inv. Status	: Limited Stock

Aripiprazole Bromobutoxyquinolinone Analog

SZ CAT No:	: SZ-A001049
CAS No	: 203395-59-9
Mol.F.	: C13H14BrNO2
Mol.Wt.	: 250.1
Inv. Status	: In Stock

Aripiprazole Impurity 25

SZ CAT No:	: SZ-A001051
CAS No	: NA
Mol.F.	: C9H8ClNO2
Mol.Wt.	: 197.6
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 26

SZ CAT No:	: SZ-A001052
CAS No	: NA
Mol.F.	: C18H16N2O4
Mol.Wt.	: 324.3
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 27

SZ CAT No:	: SZ-A001053
CAS No	: 874661-64-0
Mol.F.	: C14H19BrCl2N2
Mol.Wt.	: 366.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 28

SZ CAT No:	: SZ-A001055
CAS No	: NA
Mol.F.	: C14H21Br2Cl2N3
Mol.Wt.	: 462.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 3

SZ CAT No:	: SZ-A001033
CAS No	: 1359829-23-4
Mol.F.	: C13H15NO2
Mol.Wt.	: 217.3
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 30

SZ CAT No:	: SZ-A001058
CAS No	: NA
Mol.F.	: C14H21Cl4N3
Mol.Wt.	: 373.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 32

SZ CAT No:	: SZ-A001062
CAS No	: NA
Mol.F.	: C10H10Cl3NO
Mol.Wt.	: 266.5
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 33

SZ CAT No:	: SZ-A001063
CAS No	: NA
Mol.F.	: C10H11Cl2NO2
Mol.Wt.	: 248.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 34

SZ CAT No:	: SZ-A001064
CAS No	: 1808915-23-2
Mol.F.	: C10H9Cl2NO2
Mol.Wt.	: 246.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 35

SZ CAT No:	: SZ-A001065
CAS No	: NA
Mol.F.	: C8H8Cl3N
Mol.Wt.	: 224.5
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 36

SZ CAT No:	: SZ-A001066
CAS No	: NA
Mol.F.	: C8H9Cl2NO
Mol.Wt.	: 206.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 37

SZ CAT No:	: SZ-A001067
CAS No	: 1260893-49-9
Mol.F.	: C8H7Cl2NO
Mol.Wt.	: 204.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 38

SZ CAT No:	: SZ-A001068
CAS No	: NA
Mol.F.	: C14H12Cl4N2
Mol.Wt.	: 350.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 39

SZ CAT No:	: SZ-A001070
CAS No	: 1076199-56-8
Mol.F.	: C17H21Br2NO2
Mol.Wt.	: 431.2
Inv. Status	: In Stock

Aripiprazole Impurity 4

SZ CAT No:	: SZ-A001034
CAS No	: 1424857-63-5
Mol.F.	: C36H42Cl2N4O4
Mol.Wt.	: 665.7
Inv. Status	: In Stock

Aripiprazole Impurity 40

SZ CAT No:	: SZ-A001071
CAS No	: 2247155-46-8
Mol.F.	: C17H21BrClNO2
Mol.Wt.	: 386.7
Inv. Status	: In Stock

Aripiprazole Impurity 41

SZ CAT No:	: SZ-A001072
CAS No	: 553-03-7
Mol.F.	: C9H9NO
Mol.Wt.	: 147.2
Inv. Status	: Custom Synthesis
Rel. CAS No	: 342418-39-7 (hydrate) ; 342418-40-0 (dihydrate)

Aripiprazole Impurity 42

SZ CAT No:	: SZ-A001073
CAS No	: 1429493-91-3
Mol.F.	: C10H11NO2
Mol.Wt.	: 177.2
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 43

SZ CAT No:	: SZ-A001074
CAS No	: NA
Mol.F.	: C24H29Cl2N3O2
Mol.Wt.	: 462.4
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 44

SZ CAT No:	: SZ-A001075
CAS No	: 19315-93-6
Mol.F.	: C9H7NO2
Mol.Wt.	: 161.2
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 45

SZ CAT No:	: SZ-A001076
CAS No	: 40779-32-6
Mol.F.	: C8H10Cl2N2
Mol.Wt.	: 205.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 46

SZ CAT No:	: SZ-A001027
CAS No	: 519138-48-8
Mol.F.	: C22H26Cl4N4 : 2(HCl)
Mol.Wt.	: 488.3 : 2(36.5)
Inv. Status	: In Stock
Rel. CAS No	: 784135-99-5 (free base)

Aripiprazole Impurity 47

SZ CAT No:	: SZ-A001028
CAS No	: 1424858-02-5
Mol.F.	: C26H32N2O5
Mol.Wt.	: 452.6
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 5

SZ CAT No:	: SZ-A001035
CAS No	: 52749-50-5
Mol.F.	: C9H9NO2
Mol.Wt.	: 163.2
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 6

SZ CAT No:	: SZ-A001036
CAS No	: 63386-61-8
Mol.F.	: C10H12Cl2N2
Mol.Wt.	: 231.1
Inv. Status	: Custom Synthesis

Aripiprazole Impurity 7 HCl

SZ CAT No:	: SZ-A001037
CAS No	: 2748335-71-7
Mol.F.	: C10H13Cl3N2 : HCl
Mol.Wt.	: 267.6 : 36.5
Inv. Status	: Custom Synthesis
Rel. CAS No	: 2514942-62-0 (free base) ; 2514942-63-1 (2HCl salt)

Aripiprazole Impurity 8

SZ CAT No:	: SZ-A001038
CAS No	: 1424857-89-5
Mol.F.	: C16H17Cl4N3
Mol.Wt.	: 393.1
Inv. Status	: In Stock

2-Monobromo Aripiprazole (USP)

SZ CAT No:	: SZ-A001024
CAS No	: 203395-84-0
Mol.F.	: C23H28BrN3O2
Mol.Wt.	: 458.4
Inv. Status	: In Stock
Rel. CAS No	: 2748462-55-5 (HCl salt)

Aripiprazole Inhouse Impurity G

SZ CAT No:	: SZ-A001056
CAS No	: 129722-20-9
Mol.F.	: C23H27Cl2N3O2
Mol.Wt.	: 448.4
Inv. Status	: In Stock

Aripiprazole Iodobutoxyquinoline Impurity

SZ CAT No:	: SZ-A001019
CAS No	: 952308-47-3
Mol.F.	: C13H16INO2
Mol.Wt.	: 345.2
Inv. Status	: In Stock

Aripiprazole Lauroxil

SZ CAT No:	: SZ-A001060
CAS No	: 1259305-29-7
Mol.F.	: C36H51Cl2N3O4
Mol.Wt.	: 660.7
Inv. Status	: Custom Synthesis

Aripiprazole Methoxybutoxyquinoline Impurity

SZ CAT No:	: SZ-A001020
CAS No	: 1770391-64-4
Mol.F.	: C14H19NO3
Mol.Wt.	: 249.3
Inv. Status	: Custom Synthesis

Aripiprazole N-oxide Isomer

SZ CAT No:	: SZ-A001039
CAS No	: 573691-11-9
Mol.F.	: C23H27Cl2N3O3
Mol.Wt.	: 464.4
Inv. Status	: Custom Synthesis

Aripiprazole N-Bromobutyl Impurity

SZ CAT No:	: SZ-A001018
CAS No	: 1424857-68-0
Mol.F.	: C13H16BrNO2
Mol.Wt.	: 298.2
Inv. Status	: Custom Synthesis

Aripiprazole N-Isomer

SZ CAT No:	: SZ-A001021
CAS No	: 1797983-65-3
Mol.F.	: C23H27Cl2N3O2
Mol.Wt.	: 448.3
Inv. Status	: In Stock

Aripiprazole Nitroso Impurity 1

SZ CAT No:	: SZ-A001061
CAS No	: NA
Mol.F.	: C10H11Cl2N3O
Mol.Wt.	: 260.1
Inv. Status	: In Stock

Aripiprazole Quinolinediol Impurity

SZ CAT No:	: SZ-A001029
CAS No	: 1391054-74-2
Mol.F.	: C23H29Cl2N3O2
Mol.Wt.	: 450.4
Inv. Status	: Custom Synthesis

Aripiprazole Hydroxyquinolinone Analog

SZ CAT No:	: SZ-A001013
CAS No	: 70500-72-0
Mol.F.	: C9H7NO2
Mol.Wt.	: 161.2
Inv. Status	: In Stock

Aripiprazole USP Related Compound B

SZ CAT No:	: SZ-A001009
CAS No	: 889443-20-3
Mol.F.	: C13H17NO3
Mol.Wt.	: 235.3
Inv. Status	: In Stock

Aripiprazole USP Related Compound H

SZ CAT No:	: SZ-A001010
CAS No	: 1796928-63-6
Mol.F.	: C27H35Cl2N3O3
Mol.Wt.	: 520.4
Inv. Status	: In Stock

Chlorobutoxyquinolinone

SZ CAT No:	: SZ-A001011
CAS No	: 120004-79-7
Mol.F.	: C13H16ClNO2
Mol.Wt.	: 253.7
Inv. Status	: In Stock

Dehydro Aripiprazole D8

SZ CAT No:	: SZ-A001D02
CAS No	: 1215897-99-6
Mol.F.	: C23H17D8Cl2N3O2
Mol.Wt.	: 454.4
Inv. Status	: Custom Synthesis
Rel. CAS No	: 1215383-78-0 (HCl salt)

N-Nitroso Aripiprazole

SZ CAT No:	: SZ-A001069
CAS No	: NA
Mol.F.	: C23H26Cl2N4O3
Mol.Wt.	: 477.4
Inv. Status	: Inquire

Aripiprazole Di-N-Oxide

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