16(17)a-Homobetamethasone Sodium Phosphate

SZ CAT No:	SZ-B025062
CAS No	1201919-18-7
Mol.F.	C22H28FNa2O8P
Mol.Wt.	516.4
Inv. Status	In Stock
Rel. CAS No	1202002-01-4 (free base)

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Chemical Name: Sodium ((1S,3S,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-1,11-dihydroxy-3,10a,12a-trimethyl-2,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-1-yl)methyl phosphate ; 9-Fluoro-11β,17,21-trihydroxy-16α-methyl-16(17)a-homopregna-1,4-diene- 3,16a,20-trione 21-(dihydrogen phosphate) disodium salt (As per USP)

Synonym: D-Homo B Derivative Bethamethasone

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: C[C@@]12[C@](C[C@H](C)C([C@]2(COP(O[Na])(O[Na])=O)O)=O)([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O

Application of LC–MSn in conjunction with mechanism-based stress studies in the elucidation of drug impurity structure: Rapid identification of a process impurity in betamethasone 17-valerate drug substance
Min Li, Mingxiang Lin, Abu Rustum
Journal of Pharmaceutical and Biomedical Analysis 48 (2008) 1451–1456

Development and Validation of Stability-indicating HPLC Method for Betamethoasone Dipropionate and Related Substances in Topical Formulation
A. s. vairale*, p. sivaswaroop1 and s. bandana
Indian Journal of Pharmaceutical Sciences 74(2):107-15

16(17)a-Homobetamethasone Sodium Phosphate is chemically Sodium ((1S,3S,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-1,11-dihydroxy-3,10a,12a-trimethyl-2,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-1-yl)methyl phosphate ; 9-Fluoro-11β,17,21-trihydroxy-16α-methyl-16(17)a-homopregna-1,4-diene- 3,16a,20-trione 21-(dihydrogen phosphate) disodium salt (As per USP). It is also known as D-Homo B Derivative Bethamethasone. 16(17)a-Homobetamethasone Sodium Phosphate is supplied with detailed characterization data compliant with regulatory guideline. 16(17)a-Homobetamethasone Sodium Phosphate can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Betamethasone.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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