Chloroquine Nitroso Impurity 1

Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR
Vaijanath G. Dongrea,∗, Pradeep D. Ghugarea, Pravin Karmusea, Dharmendra Singhb, Atul Jadhav b, Ashok Kumar
Journal of Pharmaceutical and Biomedical Analysis 49 (2009) 873–879
 
Development and validation of a capillary electrophoresis assay for the determination of the stereoisomeric purity of chloroquine enantiomers
Sudaporn Wongwan Gerhard K. E. Scriba
Electrophoresis 2011, 32, 2669–2672
 
Absolute configuration of the enantiomers of 7-chloro-4-[[4-(diethylamino)-1 methylbutyl]amino]quinoline (chloroquine)
J. Cymerman Craig, Hemendra N. Bhargava, E. Thomas Everhart, Bruce LaBelle, Ulrich Ohnsorge, and Richard V. Webster
J. Org. Chem. 1988, 53, 6, 1167–1170

Chloroquine Nitroso Impurity 1 is chemically N-(4-((7-Chloroquinolin-4-yl)amino)pentyl)-N-ethylnitrous amide. Chloroquine Nitroso Impurity 1 is supplied with detailed characterization data compliant with regulatory guideline. Chloroquine Nitroso Impurity 1 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Chloroquine.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.