Tofacitinib Impurity 4

SZ CAT No:	SZ-T010074
CAS No	1675248-18-6
Mol.F.	C18H25N5O3
Mol.Wt.	359.4
Inv. Status	In Stock

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Chemical Name: Ethyl 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate

Synonym: 2-Descyano-2-ethyl Formyl-tofacitinib

Shipping Temperature: Ambient

HSN Code: 38229010

Country of Origin: India

Smiles: CN([C@H]([C@@H](CC1)C)CN1C(CC(OCC)=O)=O)C2=C(C=CN3)C3=NC=N2

Tofacitinib Impurity 4 is chemically Ethyl 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate. It is also known as 2-Descyano-2-ethyl Formyl-tofacitinib. Tofacitinib Impurity 4 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib.

The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. SynZeal products are for analytical purpose only and not for human use.

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Tofacitinib Citrate

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(3R,4S)-Tofacitinib

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Mol.F.	: C16H20N6O
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(3S,4R)-Tofacitinib

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(3S,4S)-Tofacitinib (Citrate salt)

SZ CAT No:	: SZ-T010004
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Mol.F.	: C16H20N6O : C6H8O7
Mol.Wt.	: 312.4 : 192.1
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Tofacitinib Impurity I

SZ CAT No:	: SZ-T010006
CAS No	: 1821769-41-8
Mol.F.	: C14H22N2 : 2(HCl)
Mol.Wt.	: 218.3 : 2(36.5)
Inv. Status	: Custom Synthesis

Tofacitinib Impurity J

SZ CAT No:	: SZ-T010007
CAS No	: NA
Mol.F.	: C14H22N2 : 2(HCl)
Mol.Wt.	: 218.3 : 2(36.5)
Inv. Status	: Custom Synthesis

Tofacitinib Acid Impurity

SZ CAT No:	: SZ-T010008
CAS No	: 2328165-36-0
Mol.F.	: C16H21N5O3
Mol.Wt.	: 331.4
Inv. Status	: In Stock

Tofacitinib Amide Impurity

SZ CAT No:	: SZ-T010009
CAS No	: 1675248-19-7
Mol.F.	: C16H22N6O2
Mol.Wt.	: 330.4
Inv. Status	: In Stock

Tofacitinib Impurity M

SZ CAT No:	: SZ-T010010
CAS No	: 477600-74-1
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: In Stock

Tofacitinib Impurity N

SZ CAT No:	: SZ-T010011
CAS No	: 1260614-73-0
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

Tofacitinib Benzyl Impurity

SZ CAT No:	: SZ-T010012
CAS No	: 477600-73-0
Mol.F.	: C20H25N5
Mol.Wt.	: 335.5
Inv. Status	: In Stock

Tofacitinib Impurity P

SZ CAT No:	: SZ-T010013
CAS No	: 1252883-90-1
Mol.F.	: C20H25N5
Mol.Wt.	: 335.5
Inv. Status	: Custom Synthesis

Tofacitinib Impurity Q

SZ CAT No:	: SZ-T010014
CAS No	: 3680-69-1
Mol.F.	: C6H4ClN3
Mol.Wt.	: 153.6
Inv. Status	: In Stock

Tofacitinib Impurity R

SZ CAT No:	: SZ-T010015
CAS No	: 479633-63-1
Mol.F.	: C13H10ClN3O2S
Mol.Wt.	: 307.8
Inv. Status	: In Stock

Tofacitinib Impurity S

SZ CAT No:	: SZ-T010016
CAS No	: 923036-30-0
Mol.F.	: C27H31N5O2S
Mol.Wt.	: 489.6
Inv. Status	: Custom Synthesis

Tofacitinib Impurity T

SZ CAT No:	: SZ-T010017
CAS No	: 2504210-31-3
Mol.F.	: C16H18N6O
Mol.Wt.	: 310.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity U

SZ CAT No:	: SZ-T010018
CAS No	: 1616760-97-4
Mol.F.	: C13H18ClN5
Mol.Wt.	: 279.8
Inv. Status	: Custom Synthesis

Tofacitinib Impurity V

SZ CAT No:	: SZ-T010019
CAS No	: 1616761-00-2
Mol.F.	: C16H19ClN6O
Mol.Wt.	: 346.8
Inv. Status	: In Stock

Tofacitinib Impurity W

SZ CAT No:	: SZ-T010020
CAS No	: 2504210-32-4
Mol.F.	: C13H18ClN5
Mol.Wt.	: 279.8
Inv. Status	: Custom Synthesis

Tofacitinib Impurity X

SZ CAT No:	: SZ-T010021
CAS No	: 2097982-05-1
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

Tofacitinib Impurity Y

SZ CAT No:	: SZ-T010022
CAS No	: 2227197-38-6
Mol.F.	: C14H21N5
Mol.Wt.	: 259.4
Inv. Status	: Custom Synthesis

Tofacitinib Acetyl Impurity

SZ CAT No:	: SZ-T010023
CAS No	: 477600-76-3
Mol.F.	: C15H21N5O
Mol.Wt.	: 287.4
Inv. Status	: In Stock

Tofacitinib Impurity 1

SZ CAT No:	: SZ-T010024
CAS No	: 2504210-30-2
Mol.F.	: C16H22N6O2
Mol.Wt.	: 330.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 2

SZ CAT No:	: SZ-T010025
CAS No	: 1640971-87-4
Mol.F.	: C10H17N3O : X(HCl)
Mol.Wt.	: 195.3 : X(36.5)
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 3

SZ CAT No:	: SZ-T010026
CAS No	: NA
Mol.F.	: C13H18N4O2
Mol.Wt.	: 262.3
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 6

SZ CAT No:	: SZ-T010027
CAS No	: 1092578-43-2
Mol.F.	: C16H20N6O
Mol.Wt.	: 312.4
Inv. Status	: Custom Synthesis

Tofacitinib N-Oxopropanenitrile

SZ CAT No:	: SZ-T010029
CAS No	: 2459302-77-1
Mol.F.	: C19H21N7O2
Mol.Wt.	: 379.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 7

SZ CAT No:	: SZ-T010031
CAS No	: 2504210-41-5
Mol.F.	: C29H38N10O2
Mol.Wt.	: 558.7
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 8

SZ CAT No:	: SZ-T010032
CAS No	: 2459302-78-2
Mol.F.	: C34H45N7
Mol.Wt.	: 551.8
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 9

SZ CAT No:	: SZ-T010033
CAS No	: 2374700-39-5
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 10

SZ CAT No:	: SZ-T010034
CAS No	: 1640971-60-3
Mol.F.	: C14H20N6O
Mol.Wt.	: 288.4
Inv. Status	: In Stock

Tofacitinib Impurity 11

SZ CAT No:	: SZ-T010035
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Mol.F.	: C20H25N5
Mol.Wt.	: 335.5
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Tofacitinib Impurity 12

SZ CAT No:	: SZ-T010036
CAS No	: 1092578-45-4
Mol.F.	: C20H25N5
Mol.Wt.	: 335.5
Inv. Status	: Custom Synthesis

Tofacitinib Formyl Impurity

SZ CAT No:	: SZ-T010037
CAS No	: 2227199-28-0
Mol.F.	: C14H19N5O
Mol.Wt.	: 273.3
Inv. Status	: In Stock

Tofacitinib Impurity 13

SZ CAT No:	: SZ-T010038
CAS No	: NA
Mol.F.	: C15H21N5O
Mol.Wt.	: 287.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 14

SZ CAT No:	: SZ-T010039
CAS No	: 2183519-70-0
Mol.F.	: C15H23N5
Mol.Wt.	: 273.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 15

SZ CAT No:	: SZ-T010040
CAS No	: 2056104-91-5
Mol.F.	: C27H31N5O2S
Mol.Wt.	: 489.6
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 16

SZ CAT No:	: SZ-T010041
CAS No	: 1092578-44-3
Mol.F.	: C27H31N5O2S
Mol.Wt.	: 489.6
Inv. Status	: Custom Synthesis

Tofacitinib N-Oxide Impurity 1

SZ CAT No:	: SZ-T010042
CAS No	: 2028267-73-2
Mol.F.	: C16H20N6O2
Mol.Wt.	: 328.4
Inv. Status	: In Stock

Tofacitinib Impurity 17

SZ CAT No:	: SZ-T010043
CAS No	: 2259288-22-5
Mol.F.	: C23H26N6O3S
Mol.Wt.	: 466.6
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 18

SZ CAT No:	: SZ-T010046
CAS No	: 2640342-78-3
Mol.F.	: C13H21N5 : 2(HCl)
Mol.Wt.	: 247.4 : 2(36.5)
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 19

SZ CAT No:	: SZ-T010047
CAS No	: 2459302-82-8
Mol.F.	: C19H23N7O2
Mol.Wt.	: 381.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 20

SZ CAT No:	: SZ-T010048
CAS No	: 2504210-33-5
Mol.F.	: C27H31N5OS
Mol.Wt.	: 473.7
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 22

SZ CAT No:	: SZ-T010050
CAS No	: NA
Mol.F.	: C13H18N4O2
Mol.Wt.	: 262.3
Inv. Status	: Custom Synthesis

Tofacitinib Related Impurity (PF-05579970)

SZ CAT No:	: SZ-T010052
CAS No	: NA
Mol.F.	: C15H21N5O
Mol.Wt.	: 287.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity (N-Des-(2-Cyanide-acetyl)-(3S,4R))

SZ CAT No:	: SZ-T010054
CAS No	: 2378663-15-9
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

Tofacitinib Impurity (N-Des-(2-Cyanide-acetyl)-(3R,4S))

SZ CAT No:	: SZ-T010055
CAS No	: 2459302-75-9
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

Tofacitinib N-Hydroxy Impurity

SZ CAT No:	: SZ-T010056
CAS No	: 2459302-76-0
Mol.F.	: C13H19N5O
Mol.Wt.	: 261.3
Inv. Status	: Custom Synthesis

1-Benzyl-4-Methylpiperidin-3-one

SZ CAT No:	: SZ-T010057
CAS No	: 32018-96-5
Mol.F.	: C13H17NO
Mol.Wt.	: 203.3
Inv. Status	: In Stock

Tofacitinib Impurity 24

SZ CAT No:	: SZ-T010058
CAS No	: 134965-85-8
Mol.F.	: C12H7ClN6
Mol.Wt.	: 270.7
Inv. Status	: In Stock

Tofacitinib Keto Impurity

SZ CAT No:	: SZ-T010060
CAS No	: 1236267-27-8
Mol.F.	: C16H20N6O2
Mol.Wt.	: 328.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 25

SZ CAT No:	: SZ-T010061
CAS No	: 1640971-51-2
Mol.F.	: C16H20N6O2
Mol.Wt.	: 328.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 26

SZ CAT No:	: SZ-T010062
CAS No	: 1206825-36-6
Mol.F.	: C13H19N5
Mol.Wt.	: 245.3
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 35

SZ CAT No:	: SZ-T010064
CAS No	: 2101958-24-9
Mol.F.	: C16H22N6O3
Mol.Wt.	: 346.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 59

SZ CAT No:	: SZ-T010065
CAS No	: 2101951-13-5
Mol.F.	: C16H22N6O3
Mol.Wt.	: 346.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 60

SZ CAT No:	: SZ-T010066
CAS No	: NA
Mol.F.	: C18H26N6O2
Mol.Wt.	: 358.4
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 62

SZ CAT No:	: SZ-T010068
CAS No	: NA
Mol.F.	: C16H22N6O4
Mol.Wt.	: 362.4
Inv. Status	: Custom Synthesis

5,6-Dihydro Tofacitinib

SZ CAT No:	: SZ-T010069
CAS No	: 1640972-35-5
Mol.F.	: C16H22N6O
Mol.Wt.	: 314.4
Inv. Status	: In Stock

Tofacitinib 5 Oxo Impurity

SZ CAT No:	: SZ-T010070
CAS No	: 2101951-20-4
Mol.F.	: C16H20N6O2
Mol.Wt.	: 328.4
Inv. Status	: Under Synthesis

Tofacitinib Impurity 64

SZ CAT No:	: SZ-T010071
CAS No	: NA
Mol.F.	: C21H27N7O3
Mol.Wt.	: 425.5
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 65

SZ CAT No:	: SZ-T010072
CAS No	: NA
Mol.F.	: C32H40N12O2
Mol.Wt.	: 624.8
Inv. Status	: Custom Synthesis

Tofacitinib Impurity 66

SZ CAT No:	: SZ-T010073
CAS No	: NA
Mol.F.	: C16H19ClN6O
Mol.Wt.	: 346.8
Inv. Status	: Custom Synthesis